Difference between revisions of "Mammary myofibroblastoma"

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#redirect [[Breast_pathology#Mammary_myofibroblastoma]]
'''Mammary myofibroblastoma''' is a rare benign pathology of the [[breast]].


==General==
*Rare.
*Excision = cure.
*Postmenopausal females and older males.<ref name=pmid18723968>{{Cite journal  | last1 = Qureshi | first1 = A. | last2 = Kayani | first2 = N. | title = Myofibroblastoma of breast. | journal = Indian J Pathol Microbiol | volume = 51 | issue = 3 | pages = 395-6 | month =  | year =  | doi =  | PMID = 18723968 }}</ref><ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 |    PMC = 3199680 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/?tool=pubmed}}</ref>
Note:
*In extra-mammary sites the tumour is known as a ''mammary-type myofibroblastoma'' may immunohistochemically and histomorphologically overlap with [[spindle cell lipoma]].<ref name=pmid11474286>{{Cite journal  | last1 = McMenamin | first1 = ME. | last2 = Fletcher | first2 = CD. | title = Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. | journal = Am J Surg Pathol | volume = 25 | issue = 8 | pages = 1022-9 | month = Aug | year = 2001 | doi =  | PMID = 11474286 }}</ref>
==Microscopic==
Features:<ref name=Ref_BP131>{{Ref BP|131}}</ref>
*Well-circumscribed lesion.
*Spindle cells without nuclear atypia arranged in fascicles.
*Interspersed thick bundles of collagen.
Notes:
*No calcifications.
*No necrosis.
*No hemorrhage.
DDx:
*[[Metaplastic breast carcinoma]].
*Fibromatosis.
*[[Leiomyoma]] of the breast.
*[[Nodular fasciitis]].
*[[Phyllodes tumour]].
===Images===
<gallery>
Image:Mammary_myofibroblastoma_-_low_mag.jpg | Mammary myofibroblastoma - low mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_intermed_mag.jpg | Mammary myofibroblastoma - intermed. mag. (WC/Nephron)
Image:Mammary_myofibroblastoma_-_high_mag.jpg | Mammary myofibroblastoma - high mag. (WC/Nephron)
</gallery>
www:
*[http://path.upmc.edu/cases/case249.html Mammary myofibroblastoma - several images (upmc.edu)].
==IHC==
Features:<ref name=pmid22096693>{{Cite journal  | last1 = Mele | first1 = M. | last2 = Jensen | first2 = V. | last3 = Wronecki | first3 = A. | last4 = Lelkaitis | first4 = G. | title = Myofibroblastoma of the breast: Case report and literature review. | journal = Int J Surg Case Rep | volume = 2 | issue = 6 | pages = 93-6 | month =  | year = 2011 | doi = 10.1016/j.ijscr.2011.02.006 | PMID = 22096693 }}</ref>
*CD34 +ve.<ref name=pmid11474286/>
*Desmin +ve.<ref name=pmid11474286/>
*H-caldesmon +ve.
*Actin +ve.
*Vimentin +ve.
Other
*S100 -ve.
*Beta-catenin -ve. (???)
==See also==
*[[Breast pathology]].
==References==
{{Reflist|2}}
[[Category:Breast pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 04:02, 16 February 2014

Mammary myofibroblastoma is a rare benign pathology of the breast.

General

  • Rare.
  • Excision = cure.
  • Postmenopausal females and older males.[1][2]

Note:

  • In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[3]

Microscopic

Features:[4]

  • Well-circumscribed lesion.
  • Spindle cells without nuclear atypia arranged in fascicles.
  • Interspersed thick bundles of collagen.

Notes:

  • No calcifications.
  • No necrosis.
  • No hemorrhage.

DDx:

Images

  • Mammary myofibroblastoma - low mag. (WC/Nephron)

  • Mammary myofibroblastoma - intermed. mag. (WC/Nephron)

  • Mammary myofibroblastoma - high mag. (WC/Nephron)

www:

IHC

Features:[2]

  • CD34 +ve.[3]
  • Desmin +ve.[3]
  • H-caldesmon +ve.
  • Actin +ve.
  • Vimentin +ve.

Other

  • S100 -ve.
  • Beta-catenin -ve. (???)

See also

References

  1. ↑ Qureshi, A.; Kayani, N.. "Myofibroblastoma of breast.". Indian J Pathol Microbiol 51 (3): 395-6. PMID 18723968.
  2. ↑ 2.0 2.1 Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review.". Int J Surg Case Rep 2 (6): 93-6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/. Cite error: Invalid <ref> tag; name "pmid22096693" defined multiple times with different content
  3. ↑ 3.0 3.1 3.2 McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.". Am J Surg Pathol 25 (8): 1022-9. PMID 11474286.
  4. ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 131. ISBN 978-0443066801.
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