Difference between revisions of "Lung carcinoma with EGFR mutation"

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Revision as of 17:56, 18 June 2017

Lung adenocarcinoma with EGFR rearrangement is a molecular subtype of lung adenocarcinoma.

General

Associations

Varies significantly by population:[2]

Population Prevalence Category
Europe 14% Geographic
China 38% Geographic
Females 44% Patient characteristics
Males 24% Patient characteristics
Non-smokers 49% Patient characteristics
Smokers or past smokers 22% Patient characteristics
Adenocarcinoma 38% Pathology
Non-adenocarcinoma 12% Pathology

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Lung core biopsy, left lower lobe:
	- EGFR mutation POSITIVE, ALK rearrangement NEGATIVE 

See also

References

  1. Gainor, JF.; Varghese, AM.; Ou, SH.; Kabraji, S.; Awad, MM.; Katayama, R.; Pawlak, A.; Mino-Kenudson, M. et al. (Aug 2013). "ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer.". Clin Cancer Res 19 (15): 4273-81. doi:10.1158/1078-0432.CCR-13-0318. PMID 23729361.
  2. Zhang, YL.; Yuan, JQ.; Wang, KF.; Fu, XH.; Han, XR.; Threapleton, D.; Yang, ZY.; Mao, C. et al. (Nov 2016). "The prevalence of EGFR mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis.". Oncotarget 7 (48): 78985-78993. doi:10.18632/oncotarget.12587. PMID 27738317.