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Difference between revisions of "Lung carcinoma with ALK rearrangement"
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Lung carcinoma with ALK rearrangement (view source)
Revision as of 20:47, 21 September 2017
, 20:47, 21 September 2017→General
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**Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi = | PMID = 21475126 }}</ref> | **Can be treated with ''[[crizotinib]]''.<ref name=pmid21475126>{{Cite journal | last1 = Crystal | first1 = AS. | last2 = Shaw | first2 = AT. | title = New targets in advanced NSCLC: EML4-ALK. | journal = Clin Adv Hematol Oncol | volume = 9 | issue = 3 | pages = 207-14 | month = Mar | year = 2011 | doi = | PMID = 21475126 }}</ref> | ||
***Resistance to ALK inhibitors may occur due mutations in kinase domain. | ***Resistance to ALK inhibitors may occur due mutations in kinase domain. | ||
***Ceritinib is indicated for tumor with acquired resistance to crizotinib.<ref | ***Ceritinib is indicated for tumor with acquired resistance to crizotinib.<ref>{{Cite journal | last1 = Shaw | first1 = AT. | last2 = Kim | first2 = DW. | last3 = Mehra | first3 = R. | last4 = Tan | first4 = DS. | last5 = Felip | first5 = E. | last6 = Chow | first6 = LQ. | last7 = Camidge | first7 = DR. | last8 = Vansteenkiste | first8 = J. | last9 = Sharma | first9 = S. | title = Ceritinib in ALK-rearranged non-small-cell lung cancer. | journal = N Engl J Med | volume = 370 | issue = 13 | pages = 1189-97 | month = Mar | year = 2014 | doi = 10.1056/NEJMoa1311107 | PMID = 24670165 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||