Difference between revisions of "Hypersensitivity"

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'''Hypersensitivity''' is a thingy one may get quized on.
'''Hypersensitivity''' is an inappropriate immune system response.  It is a thingy one may get quizzed on.


==Gell & Goombs classification==
==Gell & Coombs classification==
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref> Allergy, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.  
Gell & Coombs, in the 1960s, came-up with a classification that has endured.


{|Class="wikitable"
{|Class="wikitable"
! Type (I-IV)
! Type (I-IV)
! Formal name<ref>{{Ref PCPBoD8|110}}</ref>
! Name
! Name
! Example
! Example
! Etiology
! Mediator
! Pathology
|-
|-
| I
| I
| Allergy
| '''Immediate h.'''
| Example
| Allergic h.
| Etiology
| [[anaphylaxis]], (atopic) bronchial [[asthma]], allergies
| antibodies (IgE)
| mast cells, inflammation (esp. eosinophils), edema
|-
|-
| II
| II
| Cytotoxic antibody dependent
| '''Antibody mediated h.'''
| Example
| Cytotoxic antibody dependent h.
| Etiology
| [[Goodpasture syndrome]],<ref name=pmid384140>{{Cite journal  | last1 = Briggs | first1 = WA. | last2 = Johnson | first2 = JP. | last3 = Teichman | first3 = S. | last4 = Yeager | first4 = HC. | last5 = Wilson | first5 = CB. | title = Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome. | journal = Medicine (Baltimore) | volume = 58 | issue = 5 | pages = 348-61 | month = Sep | year = 1979 | doi =  | PMID = 384140 }}</ref> [[Graves disease]]
| antibodies (IgG, IgM)
| (antibody-mediated) phagocytosis & lysis
|-
|-
| III
| III
| Immune complex disease
| '''Immune complex mediated h.'''
| Example
| Immune complex mediated h.
| Etiology
| [[systemic lupus erythematosus]], [[hypersensitivity pneumonitis]],<ref name=pmid8279154>{{Cite journal  | last1 = Kaltreider | first1 = HB. | title = Hypersensitivity pneumonitis. | journal = West J Med | volume = 159 | issue = 5 | pages = 570-8 | month = Nov | year = 1993 | doi =  | PMID = 8279154 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed }}</ref> [[rheumatoid arthritis]]
| antigen-antibody complex
| inflammation, [[vasculitis]] with [[fibrinoid necrosis]]
|-
|-
| IV
| IV
| '''Cell-mediated h.'''
| Delayed-type hypersensitivity
| Delayed-type hypersensitivity
| Example
| [[tuberculosis]], [[contact dermatitis]], chronic transplant rejection, [[inflammatory bowel disease]]
| Etiology
| activated T cells
| perivascular inflammation, [[granuloma]]s
|}
|}
Memory device ''ACID'':<ref>URL: [http://www.saintcyr.com/2001/mnemonic.html http://www.saintcyr.com/2001/mnemonic.html]. Accessed on: 13 November 2011.</ref>
*Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.


==See also==
==See also==
*[[Hypersensitivity pneumonitis]].
*[[Hypersensitivity pneumonitis]].
*[[Common variable immunodeficiency]].


==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Stuff]]
[[Category:Stuff]]

Latest revision as of 14:14, 30 April 2012

Hypersensitivity is an inappropriate immune system response. It is a thingy one may get quizzed on.

Gell & Coombs classification

Gell & Coombs, in the 1960s, came-up with a classification that has endured.

Type (I-IV) Formal name[1] Name Example Mediator Pathology
I Immediate h. Allergic h. anaphylaxis, (atopic) bronchial asthma, allergies antibodies (IgE) mast cells, inflammation (esp. eosinophils), edema
II Antibody mediated h. Cytotoxic antibody dependent h. Goodpasture syndrome,[2] Graves disease antibodies (IgG, IgM) (antibody-mediated) phagocytosis & lysis
III Immune complex mediated h. Immune complex mediated h. systemic lupus erythematosus, hypersensitivity pneumonitis,[3] rheumatoid arthritis antigen-antibody complex inflammation, vasculitis with fibrinoid necrosis
IV Cell-mediated h. Delayed-type hypersensitivity tuberculosis, contact dermatitis, chronic transplant rejection, inflammatory bowel disease activated T cells perivascular inflammation, granulomas


Memory device ACID:[4]

  • Allergic, Cytotoxic-mediated, Immune-complex disease, Delayed hypersensitivity.

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 110. ISBN 978-1416054542.
  2. Briggs, WA.; Johnson, JP.; Teichman, S.; Yeager, HC.; Wilson, CB. (Sep 1979). "Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome.". Medicine (Baltimore) 58 (5): 348-61. PMID 384140.
  3. Kaltreider, HB. (Nov 1993). "Hypersensitivity pneumonitis.". West J Med 159 (5): 570-8. PMID 8279154. http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8279154/?tool=pubmed.
  4. URL: http://www.saintcyr.com/2001/mnemonic.html. Accessed on: 13 November 2011.