Difference between revisions of "Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(Created page with "'''Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma''' is a malignant epithelial tumour of the kidney associated with the here...")
 
(tweak)
Line 1: Line 1:
'''Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma''' is a malignant epithelial tumour of the [[kidney]] associated with the [[hereditary leiomyomatosis and renal cell carcinoma syndrome]].
'''Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma''' is a malignant epithelial tumour of the [[kidney]] associated with the [[hereditary leiomyomatosis and renal cell carcinoma syndrome]].
==Microscopic==
Features - renal cell carcinoma:<ref name=pmid24441663/>
*Large eosinophilic nucleolus with perinucleolar clearing - proposed hallmark - '''important'''.
**May be focal.
*Variable architecture:
**Papillary - classic description.
***Hyaline material within the fibrovascular cores - '''characteristic'''.
**Tubulopapillary.
**Tubular.
**Solid.
**[[Sieve-like pattern]]/[[cribriform]].
Notes:
*Not common: [[psammoma bodies]], foamy macrophages.<ref name=pmid11248088>{{Cite journal  | last1 = Launonen | first1 = V. | last2 = Vierimaa | first2 = O. | last3 = Kiuru | first3 = M. | last4 = Isola | first4 = J. | last5 = Roth | first5 = S. | last6 = Pukkala | first6 = E. | last7 = Sistonen | first7 = P. | last8 = Herva | first8 = R. | last9 = Aaltonen | first9 = LA. | title = Inherited susceptibility to uterine leiomyomas and renal cell cancer. | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 6 | pages = 3387-92 | month = Mar | year = 2001 | doi = 10.1073/pnas.051633798 | PMID = 11248088 }}</ref>
DDx:
*[[Papillary renal cell carcinoma]] (type 2).
*[[Tubulocystic carcinoma of the kidney]].
*[[Collecting duct carcinoma]].<ref name=pmid16597677/>
*[[Renal medullary carcinoma]] - cells also have a [[prominent nucleoli|prominent nucleolus]].
===Images===
====RCC====
<gallery>
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC -- low mag.jpg | HLRCC - low mag. (WC)
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC -- intermed mag.jpg | HLRCC - intermed mag. (WC)
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC -- high mag.jpg | HLRCC - high mag. (WC)
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - alt -- high mag.jpg | HLRCC - high mag. (WC)
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC -- very high mag.jpg | HLRCC - very high mag. (WC)
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - alt -- very high mag.jpg | HLRCC - very high mag. (WC)
</gallery>
<gallery>
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - TC-like -- low mag.jpg | HLRCC - [[tubulocystic carcinoma of the kidney|TC-like]] - low mag.
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - TC-like -- intermed mag.jpg | HLRCC - TC-like - intermed mag.
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - TC-like -- high mag.jpg | HLRCC - TC-like - high mag.
Image: Hereditary leiomyomatosis and renal cell carcinoma associated RCC - TC-like -- very high mag.jpg | HLRCC - TC-like - very high mag.
</gallery>
====www====
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC30663/figure/F3/ RCC in HLRCC (nih.gov)].<ref name=pmid11248088/>


==See also==
==See also==

Revision as of 03:14, 16 March 2016

Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma is a malignant epithelial tumour of the kidney associated with the hereditary leiomyomatosis and renal cell carcinoma syndrome.

Microscopic

Features - renal cell carcinoma:[1]

  • Large eosinophilic nucleolus with perinucleolar clearing - proposed hallmark - important.
    • May be focal.
  • Variable architecture:
    • Papillary - classic description.
      • Hyaline material within the fibrovascular cores - characteristic.
    • Tubulopapillary.
    • Tubular.
    • Solid.
    • Sieve-like pattern/cribriform.

Notes:

DDx:

Images

RCC

  • HLRCC - low mag. (WC)

  • HLRCC - intermed mag. (WC)

  • HLRCC - high mag. (WC)

  • HLRCC - high mag. (WC)

  • HLRCC - very high mag. (WC)

  • HLRCC - very high mag. (WC)

  • HLRCC - TC-like - low mag.

  • HLRCC - TC-like - intermed mag.

  • HLRCC - TC-like - high mag.

  • HLRCC - TC-like - very high mag.

www

See also

References

  1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid24441663
  2. ↑ 2.0 2.1 Launonen, V.; Vierimaa, O.; Kiuru, M.; Isola, J.; Roth, S.; Pukkala, E.; Sistonen, P.; Herva, R. et al. (Mar 2001). "Inherited susceptibility to uterine leiomyomas and renal cell cancer.". Proc Natl Acad Sci U S A 98 (6): 3387-92. doi:10.1073/pnas.051633798. PMID 11248088.
  3. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid16597677
Retrieved from "https://librepathology.org/w/index.php?title=Hereditary_leiomyomatosis_and_renal_cell_carcinoma_syndrome-associated_renal_cell_carcinoma&oldid=43265"