Gynecomastoid hyperplasia

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Gynecomastoid hyperplasia, also gynecomastia, is a benign pathology of the breast classically seen in young men.

Gynecomastoid hyperplasia
Diagnosis in short

Gynecomastoid hyperplasia. H&E stain.

Synonyms gynecomastia

LM moderate hyperplasia - glands have more than 2 cell layers, "budding" (cells jut into the lumen, buds may be multicellular -- but narrower toward the centre of the lumen), stromal palor
LM DDx Micropapillary DCIS
Site breast

Associated Dx Liver failure, Klinefelter syndrome, testicular estrogen-producing germ cell tumour
Signs excessive breast tissue
Prognosis benign
Treatment surgery

General

  • Benign enlargement of breasts in males.
    • Histologic changes may be seen in females.[1]

May be seen in the context of:

Gross

  • Excessive breast tissue in males.

Images

Microscopic

Features:[1]

  • Moderate hyperplasia.
    • Glands have more than 2 cell layers.
  • "Budding" - individual cells jut into the lumen - key feature.
    • Buds may be multicellular; however, narrower toward the centre of the lumen.
  • Stromal palor.[2]

DDx:

Images

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A. Breast Tissue (60 g), Right, Excision:
- Benign breast tissue.

B. Breast Tissue (70 g), Left, Excision:
- Benign breast tissue.

Alternate

Left Chest Mass, Excision:
- Breast tissue with gynecomastoid hyperplasia.
- NEGATIVE for malignancy.

Micro

The sections show breast tissue with epithelial hyperplasia and stromal palor. The architecture is normal. Epithelial budding is present. Significant atypia is absent.

See also

References

  1. 1.0 1.1 URL: http://www.hsc.stonybrook.edu/breast-atlas/XIII-03.htm. Accessed on: 16 November 2011.
  2. URL: http://radiology.uchc.edu/eAtlas/Breast/1693.htm. Accessed on: 16 November 2011.