Glycogen-rich clear cell carcinoma of the breast

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Glycogen-rich clear cell carcinoma of the breast
Diagnosis in short

LM groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour, variable architecture (cords, trabeculae, clusters, cribriform), minimal nuclear pleomorphism
LM DDx signet-ring cell carcinoma, lipid-rich carcinoma, apocrine carcinoma,secretory carcinoma
Stains PAS +ve, PASD -ve, Oil red O -ve
IHC BRST2 -ve
Site breast - see invasive breast cancer

Prevalence very rare
Prognosis similar to NST

Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.

It may be abbreviated GRCC.

General

Microscopic

Features:

  • Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[4]
    • Various architectural arrangements: cords, trabeculae, clusters, cribriform.
    • Minimal nuclear pleomorphism.

Notes:

DDx:

Images

www:

Stains

Features:[4]

  • PAS +ve.
  • PASD -ve.

Others:[4]

  • Oil red O -ve.
    • Lipid-rich carcinoma +ve.

IHC

Features:[3]

  • BRST2 -ve.[4]
    • Apocrine carcinoma +ve.
  • ER +ve (~62% of cases).
  • PR +ve (~62% of cases).
  • HER2 -ve (~88% of cases).

See also

References

  1. Salemis, NS. (Aug 2012). "Intraductal glycogen-rich clear cell carcinoma of the breast: a rare presentation and review of the literature.". Breast Care (Basel) 7 (4): 319-21. doi:10.1159/000341393. PMID 23904836.
  2. Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
  3. 3.0 3.1 Ma, X.; Han, Y.; Fan, Y.; Cao, X.; Wang, X. (Jan 2014). "Clinicopathologic Characteristics and Prognosis of Glycogen-Rich Clear Cell Carcinoma of the Breast.". Breast J. doi:10.1111/tbj.12231. PMID 24400866.
  4. 4.0 4.1 4.2 4.3 4.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.