Difference between revisions of "Glycogen-rich clear cell carcinoma of the breast"
Jump to navigation
Jump to search
| Line 7: | Line 7: | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[signet-ring cell carcinoma]], lipid-rich carcinoma, [[apocrine carcinoma of the breast|apocrine carcinoma]],[[Secretory carcinoma of the breast|secretory carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
Revision as of 19:13, 14 February 2014
| Glycogen-rich clear cell carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
| LM DDx | signet-ring cell carcinoma, lipid-rich carcinoma, apocrine carcinoma,secretory carcinoma |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | very rare |
Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.
It may be abbreviated GRCC.
General
- Very rare.
- Possibly a variant of apocrine carcinoma.[1]
- Prognosis usually poor.
Microscopic
Features:
- Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[2]
- Various architectural arrangements: cords, trabeculae, clusters, cribriform.
- Minimal nuclear pleomorphism.
Notes:
- Histologic appearance may be similar to hyalinizing clear cell carcinoma.
DDx:
- Signet-ring cell carcinoma.
- Lipid-rich carcinoma.
- Apocrine carcinoma.
- Secretory carcinoma.
Images
www:
Stains
Features:[2]
- PAS +ve.
- PASD -ve.
Others:[2]
- Oil red O -ve.
- Lipid-rich carcinoma +ve.
IHC
Features:[2]
- BRST2 -ve.
- Apocrine carcinoma +ve.
See also
References
- ↑ Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
- ↑ 2.0 2.1 2.2 2.3 2.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.