Difference between revisions of "Giant cell lesions"

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[[Image:Giant cell tumour of bone - very high mag.jpg|thumb|250px|[[Micrograph]] showing giant cells in a [[giant cell tumour of bone]]. [[H&E stain]].]]
'''Giant cell lesions''' appear from time to time.   
'''Giant cell lesions''' appear from time to time.   


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*True neoplasms:
*True neoplasms:
**[[Giant cell tumour of bone]].
**[[Giant cell tumour of bone]].
**Giant cell tumour of soft tissue.
**Giant cell tumour of soft tissue (peripheral giant cell granuloma). (???)
**Giant cell tumour of the jaw.
**Giant cell tumour of the jaw ([[central giant cell granuloma]]). (???)
**[[Giant cell tumour of the tendon sheath]].
**[[Undifferentiated pleomorphic sarcoma]] with giant cells.
**[[Undifferentiated pleomorphic sarcoma]] with giant cells.
**[[Osteosarcoma]] with giant cells.
**[[Osteosarcoma]] with giant cells.
**[[Aneurysmal bone cyst]]
***[[Giant cell reparative granuloma]] ([[AKA]] solid aneurysmal bone cyst<ref name=pmid22285042>{{Cite journal  | last1 = Pan | first1 = Z. | last2 = Sanger | first2 = WG. | last3 = Bridge | first3 = JA. | last4 = Hunter | first4 = WJ. | last5 = Siegal | first5 = GP. | last6 = Wei | first6 = S. | title = A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). | journal = Hum Pathol | volume =  | issue =  | pages =  | month = Jan | year = 2012 | doi = 10.1016/j.humpath.2011.10.003 | PMID = 22285042 }}</ref>).
*Non-neoplastic:
*Non-neoplastic:
**[[Brown tumour]].
**[[Brown tumour]].
*Granulomatous disease:
*Granulomatous disease:
**[[Sarcoidosis]].
**[[Sarcoidosis]].
**Other granulomatous disease.
**Other [[granuloma|granulomatous]] disease.
***Foreign body giant cells.
*Other:
**[[Syncytiotrophoblasts]]:
***[[Choriocarcinoma]].
***May be seen in [[seminoma]]/[[germinoma]].<ref name=pmid157614>{{Cite journal  | last1 = Hedinger | first1 = C. | last2 = von Hochstetter | first2 = AR. | last3 = Egloff | first3 = B. | title = Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma. | journal = Virchows Arch A Pathol Anat Histol | volume = 383 | issue = 1 | pages = 59-67 | month = Jul | year = 1979 | doi =  | PMID = 157614 }}</ref><ref name=pmid6542213>{{Cite journal  | last1 = Drut | first1 = R. | last2 = Jones | first2 = MC. | title = Germinoma of the pineal body with syncytiotrophoblastic giant cells. | journal = Pediatr Pathol | volume = 2 | issue = 1 | pages = 65-70 | month =  | year = 1984 | doi =  | PMID = 6542213 }}</ref>
**[[Malignant melanoma]].
**"[[Giant cell cystitis]]".
**Others.


==See also==
==See also==
*[[Bone]].
*[[Giant cells]].
*[[Giant cells]].
*[[GCT]] - an abbreviation used for ''giant cell tumour'' and other tumours.
*[[Nuclear pleomorphism]].


==References==
==References==

Latest revision as of 21:43, 2 November 2016

Giant cell lesions appear from time to time.

The DDx is large:[1]

See also

References

  1. Salzer-Kuntschik M (1998). "[Differential diagnosis of giant cell tumor of bone]" (in German). Verh Dtsch Ges Pathol 82: 154–9. PMID 10095427.
  2. Pan, Z.; Sanger, WG.; Bridge, JA.; Hunter, WJ.; Siegal, GP.; Wei, S. (Jan 2012). "A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst).". Hum Pathol. doi:10.1016/j.humpath.2011.10.003. PMID 22285042.
  3. Hedinger, C.; von Hochstetter, AR.; Egloff, B. (Jul 1979). "Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma.". Virchows Arch A Pathol Anat Histol 383 (1): 59-67. PMID 157614.
  4. Drut, R.; Jones, MC. (1984). "Germinoma of the pineal body with syncytiotrophoblastic giant cells.". Pediatr Pathol 2 (1): 65-70. PMID 6542213.