Difference between revisions of "Forensic pathology"

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Forensic pathology (view source)

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=Death categorization=
=Death categorization=
Deaths are categorized foremost by manner and '''manner of death''' is the most important legal aspect of death.  
Deaths are categorized foremost by the '''manner of death'''. The manner is the single most important legal categorization for a death.  
The '''cause of death''' is of secondary important and is essential for understanding what happened.  The '''mechanism of death''' is the pathophysiologic reason for death.
The '''cause of death''' is important for understanding what happened.  The '''mechanism of death''' is the pathophysiologic reason for death and can be inferred from the cause.


Examples:
Examples:
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!Scenario
!Scenario
|-
|-
|[[Electrocution]]
| [[Electrocution]]
|accident
| accident
|cardiac arrhythmia
| [[cardiac arrhythmia]]
|man struck by lightening
| man struck by lightning
|-
|-
|Hyperthermia
| Hyperthermia
|accident
| accident
|arrhythmias, seizures<ref name=fmuk>URL: [http://www.forensicmed.co.uk/pathology/mechanisms-of-death/ http://www.forensicmed.co.uk/pathology/mechanisms-of-death/]. Accessed on: 19 April 2012.</ref>
| arrhythmias, seizures<ref name=fmuk>URL: [http://www.forensicmed.co.uk/pathology/mechanisms-of-death/ http://www.forensicmed.co.uk/pathology/mechanisms-of-death/]. Accessed on: 19 April 2012.</ref>
|man lost on hiking trip in desert
| man lost on hiking trip in desert
|-
|-
|[[Epidural hemorrhage]] due to [[blunt force trauma]] to the head
| [[Epidural hemorrhage]] due to [[blunt force trauma]] to the head
|homicide
| homicide
|brain stem compression or cerebral vascular spasm leading to autonomic dysregulation
| brain stem compression or cerebral vascular spasm leading to autonomic dysregulation
|man hit with a hammer in the head
| man hit with a hammer in the head
|-
|-
|[[Carbon monoxide toxicity]]
| [[Carbon monoxide toxicity]]
|suicide
| suicide
|cerebral hypoxia (CO binds to hemoglobin impairing oxygen transport)
| cerebral hypoxia (CO binds to hemoglobin impairing oxygen transport)
|woman found in car with suicide note, long history of depression
| woman found in car with suicide note, long history of depression, previous suicide attempts
|-
|-
|[[Atherosclerotic heart disease]]
| [[Atherosclerotic heart disease]]
|natural
| natural
|cardiac arrhythmia due to ischemia
| cardiac arrhythmia due to ischemia
|man has 95% stenosis of LMCA - no other significant autopsy findings
| man found dead in bed, apartment locked, 95% stenosis of LMCA at autopsy, no other significant autopsy findings
|- <!--
| [[Peritonitis]] due to duodenal perforation as a consequence of [[peptic ulcer disease]]
| natural
| cerebral hypoxia secondary to hypotension
| man found in locked apartment, complained of abdominal pain before dead
|-
| Coronary artery stent thrombosis complicating the treatment of a [[myocardial infarction]] due to atherosclerotic heart disease
| natural
| cardiac arrhythmia due to ischemia
| woman found dead following hospital stay for a myocardial infarction, post-angioplasty and coronary stenting -->
|}
|}


==Manner of death==
==Manner of death==
The manner of death is a legislatively defined classification. It varies slightly between jurisdictions.
<!--
<!--
MANNER OF DEATH
MANNER OF DEATH
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==Mechanism of death==
==Mechanism of death==
This is occasionally of interest. It is usually based on physiology.
This is occasionally of interest. It is usually based on physiology.  
 
The mechanism is often asked for [[asphyxial death]]s. The short answer it is: brain stem hypoxia due to ischemia caused by venous obstruction in the neck.<ref>URL: [http://www.forensicmed.co.uk/pathology/mechanisms-of-death/ http://www.forensicmed.co.uk/pathology/mechanisms-of-death/]. Accessed on: 1 May 2012.</ref><ref>URL: [http://www.forensicmed.co.uk/pathology/pressure-to-the-neck/ http://www.forensicmed.co.uk/pathology/pressure-to-the-neck/]. Accessed on: 1 May 2012.</ref>


==Cause of death==
==Cause of death==
*Abbreviated ''COD''.
===General===
===General===
*The cause of death should be what started the sequence of events that lead to death.
*The cause of death should be what started the sequence of events that lead to death.


===="Word form"====
====Word form for cause of death====
Example:
Examples:
*''[[C. difficile colitis]] complicating antibiotic treatment for a dental abscess''.<ref>MSP. 8 September 2010.</ref>
*''[[C. difficile colitis]] complicating antibiotic treatment for a dental abscess''.<ref>MSP. 8 September 2010.</ref>
*''Complications of laparoscopic cholecystectomy for ascending cholangitis with [[mesothelioma]] and atherosclerotic heart disease''.<ref>TR. 3 September 2010.</ref>
*''Complications of laparoscopic cholecystectomy for ascending cholangitis with [[mesothelioma]] and atherosclerotic heart disease''.<ref>TR. 3 September 2010.</ref>
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*''A'' complicating ''B'' for the treatment of ''C'' with ''D'' and ''E''.
*''A'' complicating ''B'' for the treatment of ''C'' with ''D'' and ''E''.


====WHO form====
====World Health Organization form for cause of death====
General form:<ref name=pmid15914304>{{cite journal |author=Pollanen MS |title=Deciding the cause of death after autopsy--revisited |journal=J Clin Forensic Med |volume=12 |issue=3 |pages=113–21 |year=2005 |month=June |pmid=15914304 |doi=10.1016/j.jcfm.2005.02.004 |url=}}</ref>
General form:<ref name=pmid15914304>{{cite journal |author=Pollanen MS |title=Deciding the cause of death after autopsy--revisited |journal=J Clin Forensic Med |volume=12 |issue=3 |pages=113–21 |year=2005 |month=June |pmid=15914304 |doi=10.1016/j.jcfm.2005.02.004 |url=}}</ref>
*1a = immediate cause of death.
*1a = ''immediate cause of death''.
*1b = what lead to the immediate cause of death.
*1b = what lead to the ''immediate cause of death''.
*1c... 1[x] -- where 'x' is the last letter used; 1x = What started the sequence of events.
*1c... 1[x] -- where 'x' is the last letter used; 1x = What started the sequence of events. This is known as the ''underlying cause of death''.
*2 = contributing factors.
*2 = contributing factors.


Example 1:
Example 1:
*1a. Ketoacidosis.
*1a. [[Ketoacidosis]].
*1b. Diabetes mellitus.
*1b. [[Diabetes mellitus]].
*1c. Alcoholism.
*2. [[Alcoholism]] and acute [[bronchopneumonia]].
*2.  Acute bronchopneumonia.


Example 2:
Example 2:
*1a. Hemoperitoneum.
*1a. Hemoperitoneum.
*1b. Splenic laceration.
*1b. [[Splenic laceration]].
*1c. Blunt force trauma.
*1c. Blunt force trauma.
*2. Liver [[cirrhosis]].
*2. Liver [[cirrhosis]].


===Natural deaths===
===Natural deaths===
{{Main|Natural death}}
*The cause should be a medical diagnosis, '''not''' the mechanism (e.g. ''cardiac arrest'', ''cachexia'', ''kidney failure'').
*The cause should be a medical diagnosis, '''not''' the mechanism (e.g. ''cardiac arrest'', ''cachexia'', ''kidney failure'').
*The mechanism is irrelevant.
*The [[mechanism of death|mechanism]] is irrelevant.


Notes:
Notes:
*Unnatural causes trump natural ones.  If a guy with (nothing more than) a 70% proximal LAD stenosis and an old [[myocardial infarct]] is found in the water, they are usually called drowning.
*Unnatural causes trump natural ones.  If a guy with (nothing more than) a 70% proximal LAD stenosis and an old [[myocardial infarct]] is found in the water, they are usually called [[drowning]].
*Cancer is rarely the immediate cause of death - it is usually something else.<ref>PS. 2009.</ref>
*[[Cancer]] is rarely the immediate cause of death - it is usually something else.<ref>Shannon, P. 2009.</ref>
*Things (mechanisms) that shouldn't be used: [http://www.pallimed.org/2008/03/unacceptable-causes-of-death-other-web.html http://www.pallimed.org/2008/03/unacceptable-causes-of-death-other-web.html]
*Things (mechanisms) that shouldn't be used: [http://www.pallimed.org/2008/03/unacceptable-causes-of-death-other-web.html http://www.pallimed.org/2008/03/unacceptable-causes-of-death-other-web.html]


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====General====
====General====
*In Ontario, the ''manner'' is determined by the coroner.
*In Ontario, the ''manner'' is determined by the coroner.
*Coroners, in Ontario, are MDs -- usually family docs.
*Coroners, in Ontario, are MDs -- usually [[family docs]].
*The cause (e.g. "gunshot wound to the head") is determined by the pathologist.
*The cause (e.g. "gunshot wound to the head") is determined by the pathologist.


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**Haemorrhage (e.g. cerebral bleed, gastrointestinal bleed, aortic aneurysm).
**Haemorrhage (e.g. cerebral bleed, gastrointestinal bleed, aortic aneurysm).
**Infection (e.g. [[pneumonia]]).
**Infection (e.g. [[pneumonia]]).
**Coronary [[atherosclerosis]] (cardiac arrhythmias - more common in the forensic context than myocardial infarction (MI); individuals with MIs don't usu. drop dead-- they go to the ER).
**[[Coronary artery atherosclerosis]] ([[cardiac arrhythmia]]s - more common in the forensic context than [[myocardial infarction]] (MI); individuals with MIs don't usu. drop dead-- they go to the ER).
***Post [[myocardial infarction]] (free wall rupture).
***Post [[myocardial infarction]] (free wall rupture).
***Ruptured (atherosclerotic) plaque.
***Ruptured (atherosclerotic) plaque.
*Toxic (memory device: ''PAIRO''):
*Toxic (memory device: ''PAIRO''):
**Poisons.
**Poisons.
**Alcohol (EtOH).  
**[[Alcohol]] (EtOH).  
**Illicit (e.g. [[cocaine]], heroin, LSD).  
**Illicit (e.g. [[cocaine]], heroin, LSD).  
**Rx.  
**Rx.  
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=Wounds=
=Wounds=
===Classification (gross pathology)===
==General==
*''Wound'' - definition: defect in skin or mucous membrane<ref>URL: [http://dictionary.reference.com/browse/wound http://dictionary.reference.com/browse/wound]. Accessed on: 20 April 2012.</ref> - usually due to trauma.
 
Special types of wounds:
*[[Gunshot wounds]].
*Incised wounds - see [[sharp force trauma]].
 
===Gross pathologic classification of injuries===
Mnemonic ''CALI'':
Mnemonic ''CALI'':
*'''C'''ontusion - "bruise", haematoma.
*'''C'''ontusion - "bruise", [[hematoma]].
**Age (usual colour change sequence): red, blue, green, yellow, brown.<ref name=Ref_HospAuto108>{{Ref HospAuto|108}}</ref>
**Age (usual colour change sequence): red, blue, green, yellow, brown.<ref name=Ref_HospAuto108>{{Ref HospAuto|108}}</ref>
**Etiology: bleeding from arterioles or venules (not capillaries).<ref name=Ref_HospAuto105>{{Ref HospAuto|105}}</ref>
**Etiology: bleeding from arterioles or venules (not capillaries).<ref name=Ref_HospAuto105>{{Ref HospAuto|105}}</ref>
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***Skin tags suggest directionality; they are found at the distal point / point of last contact.<ref name=Ref_HospAuto105>{{Ref HospAuto|105}}</ref>
***Skin tags suggest directionality; they are found at the distal point / point of last contact.<ref name=Ref_HospAuto105>{{Ref HospAuto|105}}</ref>
*'''L'''aceration - "tear", indicates blunt force trauma; contact point may be distant from where skin splits.
*'''L'''aceration - "tear", indicates blunt force trauma; contact point may be distant from where skin splits.
*'''I'''ncised - "cut", e.g. caused by a knife.<ref name=Ref_HoFP154>{{Ref_HoFP|154}}</ref>
*'''I'''ncised - "cut", e.g. caused by a knife,<ref name=Ref_HoFP154>{{Ref_HoFP|154}}</ref> subdivided as follows:
*#"Cut" or "slash" = length > depth.
*#"Cut" or "slash" = length > depth.
*#"Stab" = depth > length.
*#"Stab" = depth > length.
*#"Chop" = typically have a contusion at the margin of the wound, classically caused by an axe. May be caused by a propeller.<ref name=pmid19733336>{{Cite journal  | last1 = Ihama | first1 = Y. | last2 = Ninomiya | first2 = K. | last3 = Noguchi | first3 = M. | last4 = Fuke | first4 = C. | last5 = Miyazaki | first5 = T. | title = Fatal propeller injuries: three autopsy case reports. | journal = J Forensic Leg Med | volume = 16 | issue = 7 | pages = 420-3 | month = Oct | year = 2009 | doi = 10.1016/j.jflm.2009.04.006 | PMID = 19733336 }}</ref>


====Images====
<gallery>
Image:Hand_Abrasion_-_32_minutes_after_injury.JPG | Abrasion. (WC)
Image:Black_eye_2.jpg | Contusion ("black eye"). (WC)
</gallery>
====DDx====
====DDx====
How to decide what you're looking at:
How to decide what you're looking at:
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**Lacerations are classically on the skull and face.  They are rarely on the abdomen.
**Lacerations are classically on the skull and face.  They are rarely on the abdomen.


===Dating===
===Wound dating===
*Colour is somewhat useful for bruises.
*Colour is somewhat useful for contusions (bruises).
*Post-mortem injuries tend to be orange-yellow.<ref name=pmid19237864>{{Cite journal  | last1 = Campobasso | first1 = CP. | last2 = Marchetti | first2 = D. | last3 = Introna | first3 = F. | last4 = Colonna | first4 = MF. | title = Postmortem artifacts made by ants and the effect of ant activity on decompositional rates. | journal = Am J Forensic Med Pathol | volume = 30 | issue = 1 | pages = 84-7 | month = Mar | year = 2009 | doi = 10.1097/PAF.0b013e318187371f | PMID = 19237864 }}</ref>
*Post-mortem injuries tend to be orange-yellow.<ref name=pmid19237864>{{Cite journal  | last1 = Campobasso | first1 = CP. | last2 = Marchetti | first2 = D. | last3 = Introna | first3 = F. | last4 = Colonna | first4 = MF. | title = Postmortem artifacts made by ants and the effect of ant activity on decompositional rates. | journal = Am J Forensic Med Pathol | volume = 30 | issue = 1 | pages = 84-7 | month = Mar | year = 2009 | doi = 10.1097/PAF.0b013e318187371f | PMID = 19237864 }}</ref>
*Wounds age is difficult to determine as [[wound healing]] is affected by a large number of variables.
*Old wounds (scars), generally, cannot be dated - one can only say they are ''old''.


===Microscopic===
===Microscopic===
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**[[PMN]]s 6-24 hours after injury.
**[[PMN]]s 6-24 hours after injury.
**PMNs replaced monocytes in 24-48 hours.
**PMNs replaced monocytes in 24-48 hours.
===Stains===
*[[Iron stain]] for siderophages (hemosiderin-laden macrophages) -- presence suggests 2-3 days or older.<ref name=pmid7529545>{{Cite journal  | last1 = Betz | first1 = P. | title = Histological and enzyme histochemical parameters for the age estimation of human skin wounds. | journal = Int J Legal Med | volume = 107 | issue = 2 | pages = 60-8 | month =  | year = 1994 | doi =  | PMID = 7529545 }}</ref>


=Bone fractures=
=Bone fractures=
*[[AKA]] ''fractures''.
*[[AKA]] ''fractures''.
*[[AKA]] ''fracture of bone''.
==Artefactual fractures==
==Artefactual fractures==
*"Undertaker's fracture" - cervical fracture due to rough handling.<ref>URL: [http://www.the-crankshaft.info/2010/07/postmortem-changes_29.html http://www.the-crankshaft.info/2010/07/postmortem-changes_29.html]. Accessed on: 29 September 2010.</ref>
*"Undertaker's fracture" - cervical fracture due to rough handling.<ref>URL: [http://www.the-crankshaft.info/2010/07/postmortem-changes_29.html http://www.the-crankshaft.info/2010/07/postmortem-changes_29.html]. Accessed on: 29 September 2010.</ref>
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==Healing of fractures==
==Healing of fractures==
Simplified classification:
===Simplified classification===
*Primary callus (cartilaginous) - early.
*Primary callus (cartilaginous) - early.
*Secondary callus (bone) - late.
*Secondary callus (bone) - late.
===Microscopic===
Features:
*Fragmentation of bone.
*+/-Dead bone = lacunae have no osteocytes.<ref name=pmid22460748>{{Cite journal  | last1 = Fondi | first1 = C. | last2 = Franchi | first2 = A. | title = Definition of bone necrosis by the pathologist. | journal = Clin Cases Miner Bone Metab | volume = 4 | issue = 1 | pages = 21-6 | month = Jan | year = 2007 | doi =  | PMID = 22460748 }}</ref>
**Takes days for osteocyte loss.
*+/-Inflammatory cells.
*+/-Hemosiderin-laden macrophages.
*+/-Osteoblastic rimming.
DDx:
*Fracture secondary to a tumour:
**Metastatic carcinoma.
**[[Osteosarcoma]] - typically does '''not''' have osteoblastic rimming.


Notes:
Notes:
*Radiology is not good at dating fratures,<ref name=pmid15788611>{{Cite journal  | last1 = Prosser | first1 = I. | last2 = Maguire | first2 = S. | last3 = Harrison | first3 = SK. | last4 = Mann | first4 = M. | last5 = Sibert | first5 = JR. | last6 = Kemp | first6 = AM. | title = How old is this fracture? Radiologic dating of fractures in children: a systematic review. | journal = AJR Am J Roentgenol | volume = 184 | issue = 4 | pages = 1282-6 | month = Apr | year = 2005 | doi =  | PMID = 15788611 | url=http://www.ajronline.org/cgi/content/full/184/4/1282 }}
*Radiology is not good at dating fratures;<ref name=pmid15788611>{{Cite journal  | last1 = Prosser | first1 = I. | last2 = Maguire | first2 = S. | last3 = Harrison | first3 = SK. | last4 = Mann | first4 = M. | last5 = Sibert | first5 = JR. | last6 = Kemp | first6 = AM. | title = How old is this fracture? Radiologic dating of fractures in children: a systematic review. | journal = AJR Am J Roentgenol | volume = 184 | issue = 4 | pages = 1282-6 | month = Apr | year = 2005 | doi =  | PMID = 15788611 | url=http://www.ajronline.org/cgi/content/full/184/4/1282 }}
</ref> but good at finding 'em.
</ref> however, it is good at finding 'em.


==Pattern and cause==
==Pattern and cause==
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*Complete hinge fractures are considered severe; they are a 4 on the ''abbreviated injury scale'' (AIS).<ref>{{Cite journal  | last1 = Adams | first1 = VI. | last2 = Carrubba | first2 = C. | title = The Abbreviated Injury Scale: application to autopsy data. | journal = Am J Forensic Med Pathol | volume = 19 | issue = 3 | pages = 246-51 | month = Sep | year = 1998 | doi =  | PMID = 9760090 }}</ref>
*Complete hinge fractures are considered severe; they are a 4 on the ''abbreviated injury scale'' (AIS).<ref>{{Cite journal  | last1 = Adams | first1 = VI. | last2 = Carrubba | first2 = C. | title = The Abbreviated Injury Scale: application to autopsy data. | journal = Am J Forensic Med Pathol | volume = 19 | issue = 3 | pages = 246-51 | month = Sep | year = 1998 | doi =  | PMID = 9760090 }}</ref>
*Classically due to a blow to the chin - resulting in a fracture across the medial fossa and sella turcica.<ref>URL: [http://wiki.answers.com/Q/Hinge_fracture_of_skull_is_seen_in_accidents_involving http://wiki.answers.com/Q/Hinge_fracture_of_skull_is_seen_in_accidents_involving]. Accessed on: 28 March 2012.</ref>
*Classically due to a blow to the chin - resulting in a fracture across the medial fossa and sella turcica.<ref>URL: [http://wiki.answers.com/Q/Hinge_fracture_of_skull_is_seen_in_accidents_involving http://wiki.answers.com/Q/Hinge_fracture_of_skull_is_seen_in_accidents_involving]. Accessed on: 28 March 2012.</ref>
===Pathologic fracture===
{{Main|Pathologic fracture}}
*A fracture due to an underlying pathology.
===Hip fractures===
*[[Traumatic fracture of the femoral neck]].


=Autopsy=
=Autopsy=
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==Environmental==
==Environmental==
Includes:  
{{Main|Environmental causes of death}}
*Hypothermia.  
They include:  
*Hyperthermia.  
*[[Hypothermia]].  
*[[Hyperthermia]].  
*Drowning - see [[asphyxial deaths]].
*Drowning - see [[asphyxial deaths]].
*Lack of oxygen - see [[asphyxial deaths]].  
*Lack of oxygen - see [[asphyxial deaths]].  
*Electrocution.
*[[Electrocution]].
 
===Hypothermia===
Features:<ref name=>{{cite journal |author=E. E. Türk, J. P. Sperhake, K. Pueschel and Michael Tsokos |title=An approach to the evaluation of fatal hypothermia |journal=Forensic Science, Medicine, and Pathology |volume=1 |issue=1 |pages=31–35 |year=2005 |month= |pmid= |doi= |url=http://www.springerlink.com/content/n785314u75m71j8h/fulltext.pdf}}</ref>
*Reddening of exposed skin areas "frost erythema" - '''classic feature'''.
*Wischnewski spots ([[AKA]] Leopard spots) - '''classic feature'''.
**Brown/black spots of the gastric mucosa ~ 0.1-0.4 cm; thought to represent pre-mortem/perimortem hemorrhage.<ref>{{cite journal |author=Tsokos M, Rothschild MA, Madea B, Rie M, Sperhake JP |title=Histological and immunohistochemical study of Wischnewsky spots in fatal hypothermia |journal=Am J Forensic Med Pathol |volume=27 |issue=1 |pages=70–4 |year=2006 |month=March |pmid=16501354 |doi=10.1097/01.paf.0000202716.06378.91 |url=http://journals.lww.com/amjforensicmedicine/Abstract/2006/03000/Histological_and_Immunohistochemical_Study_of.14.aspx}}</ref>
*Paradoxical undressing; decedent has removed clothes due to perception of being too hot.<ref name=pmid20151230>{{cite journal |author=Turk EE |title=Hypothermia |journal=Forensic Sci Med Pathol |volume=6 |issue=2 |pages=106–15 |year=2010 |month=June |pmid=20151230 |doi=10.1007/s12024-010-9142-4 |url=}}</ref>
 
Notes:
*Findings are often non-specific.<ref name=pmid16948514>{{cite journal |author=Nixdorf-Miller A, Hunsaker DM, Hunsaker JC |title=Hypothermia and hyperthermia medicolegal investigation of morbidity and mortality from exposure to environmental temperature extremes |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=9 |pages=1297–304 |year=2006 |month=September |pmid=16948514 |doi= |url=http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165%282006%29130%5B1297%3AHAHMIO%5D2.0.CO%3B2}}</ref>
*Non-specific findings seen in hypothermia:<ref name=pmid16948514/>
**[[Pulmonary edema]].
**Hemorrhagic pancreatitis.
**Hemorrhage of the iliopsoas muscle.
*DDx of reddening of skin includes [[Carbon_monoxide toxicity|carbon monoxide poisoning]].
Image:
*[http://www.springerlink.com/content/n785314u75m71j8h/fulltext.pdf Wischnewski spots (springerlink.com)].
 
===Hyperthermia===
Features:
*Findings are non-specific.<ref name=pmid16948514>{{cite journal |author=Nixdorf-Miller A, Hunsaker DM, Hunsaker JC |title=Hypothermia and hyperthermia medicolegal investigation of morbidity and mortality from exposure to environmental temperature extremes |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=9 |pages=1297–304 |year=2006 |month=September |pmid=16948514 |doi= |url=http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165%282006%29130%5B1297%3AHAHMIO%5D2.0.CO%3B2}}</ref>
*Short survival:
**+/-Petechiae - serosal (pleural, epicardial, pericardial) and cerebral periventricular.
**+/-Cerebral edema.
*Long survival:
**Findings consistent with hypovolemic shock (hepatic [[necrosis]], cerebral edema, [[DAD]] in lung, acute [[pancreatitis]]).
**Clinical/biochemical: [[rhabdomyolysis]], [[DIC]], [[ATN]].
 
===Electrocution===
====General====
*May be missed - as can be subtle.
*Usually causes death by cardiac arrhythmia.
*Typically accidents.<ref>{{Cite journal  | last1 = Wick | first1 = R. | last2 = Gilbert | first2 = JD. | last3 = Simpson | first3 = E. | last4 = Byard | first4 = RW. | title = Fatal electrocution in adults--a 30-year study. | journal = Med Sci Law | volume = 46 | issue = 2 | pages = 166-72 | month = Apr | year = 2006 | doi =  | PMID = 16683472 }}</ref>
*Occasionally used to suicide.<ref name=pmid19298463>{{Cite journal  | last1 = Dokov | first1 = W. | title = Forensic characteristics of suicide by electrocution in Bulgaria. | journal = J Forensic Sci | volume = 54 | issue = 3 | pages = 669-71 | month = May | year = 2009 | doi = 10.1111/j.1556-4029.2009.01002.x | PMID = 19298463 }}</ref>
 
====Gross features====
*Usually burns on the hands - brown.
**Typically absent if it happened in a wet environment.<ref name=pmid12062943>{{Cite journal  | last1 = Karger | first1 = B. | last2 = Süggeler | first2 = O. | last3 = Brinkmann | first3 = B. | title = Electrocution--autopsy study with emphasis on electrical petechiae. | journal = Forensic Sci Int | volume = 126 | issue = 3 | pages = 210-3 | month = May | year = 2002 | doi =  | PMID = 12062943 }}</ref>
*Focal injury suggestive of high voltage (> 1000 V).
*Lichtenberg figure = fern-like figure.
 
Image:
*[http://en.wikipedia.org/wiki/File:Js_photo_4.png Lichtenberg figure (WP)].
====Microscopic====
Features:
*Palisading of basal cells (like cautery artefact).


=Gunshot wounds=
=Gunshot wounds=
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**Includes: smothering, [[choking]], positional asphyxia, [[drowning]].
**Includes: smothering, [[choking]], positional asphyxia, [[drowning]].


==Blunt force trauma==
=Blunt force injury=
===General===
*[[AKA]] ''blunt force trauma''.
*Weapon: fist, foot, baseball bat... pretty much anything.
==General==
Classification:
*Contusions.
*Laceration.
*Acceleration/deceleration injury, e.g. [[diffuse axonal injury]].
 
Weapons:  
*Fist.
*Foot.
*Baseball bat... pretty much anything.
*Beer bottles are common... and strong enought to fracture a skull.
*Beer bottles are common... and strong enought to fracture a skull.
**Empty bottles have a higher fracture energy than full ones.<ref name=pmid19239964>{{cite journal |author=Bolliger SA, Ross S, Oesterhelweg L, Thali MJ, Kneubuehl BP |title=Are full or empty beer bottles sturdier and does their fracture-threshold suffice to break the human skull? |journal=J Forensic Leg Med |volume=16 |issue=3 |pages=138–42 |year=2009 |month=April |pmid=19239964 |doi=10.1016/j.jflm.2008.07.013 |url=}}</ref>
**Empty bottles have a higher fracture energy than full ones.<ref name=pmid19239964>{{cite journal |author=Bolliger SA, Ross S, Oesterhelweg L, Thali MJ, Kneubuehl BP |title=Are full or empty beer bottles sturdier and does their fracture-threshold suffice to break the human skull? |journal=J Forensic Leg Med |volume=16 |issue=3 |pages=138–42 |year=2009 |month=April |pmid=19239964 |doi=10.1016/j.jflm.2008.07.013 |url=}}</ref>


==Cause of death==
===Commotio cordis===
===Commotio cordis===
Features:<ref name=pmid11334832>{{cite journal |author=Kohl P, Nesbitt AD, Cooper PJ, Lei M |title=Sudden cardiac death by Commotio cordis: role of mechano-electric feedback |journal=Cardiovasc. Res. |volume=50 |issue=2 |pages=280–9 |year=2001 |month=May |pmid=11334832 |doi= |url=}}</ref><ref>{{cite journal |author=Maron BJ, Estes NA |title=Commotio cordis |journal=N. Engl. J. Med. |volume=362 |issue=10 |pages=917–27 |year=2010 |month=March |pmid=20220186 |doi=10.1056/NEJMra0910111 |url=http://www.nejm.org/doi/full/10.1056/NEJMra0910111}}</ref>
Features:<ref name=pmid11334832>{{cite journal |author=Kohl P, Nesbitt AD, Cooper PJ, Lei M |title=Sudden cardiac death by Commotio cordis: role of mechano-electric feedback |journal=Cardiovasc. Res. |volume=50 |issue=2 |pages=280–9 |year=2001 |month=May |pmid=11334832 |doi= |url=}}</ref><ref>{{cite journal |author=Maron BJ, Estes NA |title=Commotio cordis |journal=N. Engl. J. Med. |volume=362 |issue=10 |pages=917–27 |year=2010 |month=March |pmid=20220186 |doi=10.1056/NEJMra0910111 |url=http://www.nejm.org/doi/full/10.1056/NEJMra0910111}}</ref>
*Often negative autopsy; no cardiac pathology.
*Often negative autopsy; no cardiac pathology.
*Etiology: arrhythmia.
*Etiology: [[cardiac arrhythmia|arrhythmia]].
*History: trauma to chest.
*History: trauma to chest.


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*Analogous to ''[[commotio medullaris]]''.
*Analogous to ''[[commotio medullaris]]''.


==Scenarios==
===Motor vehicle collisions===
===Motor vehicle collisions===
*Pedestrian vs. motor vehicle: heel to injury measurement.<ref>{{Ref OPMfP|18}}</ref>
*Pedestrian vs. motor vehicle: heel to injury measurement, remember to include the thickness of the heel/sole of shoe.<ref>{{Ref OPMfP|18}}</ref>
===Seromuscular tear===
*Dicing injuries: tempered glass used in side window construction fragments into cubes when fractured causing L-shaped wounds.
* [[AKA]] ''seatbeat syndrome''.
* Intestinal injury associated with motor vehicle collisions and more specifically seatbelts.
 
Features:
* Def'n: separation of (inner) muscularis propria from submucosa.<ref name=pmid12198344>{{Cite journal  | last1 = Slavin | first1 = RE. | last2 = Borzotta | first2 = AP. | title = The seromuscular tear and other intestinal lesions in the seatbelt syndrome: a clinical and pathologic study of 29 cases. | journal = Am J Forensic Med Pathol | volume = 23 | issue = 3 | pages = 214-22 | month = Sep | year = 2002 | doi = 10.1097/01.PAF.0000023001.32202.2D | PMID = 12198344 }}</ref>


===Descent from height===
===Descent from height===
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*+/-Haemoaspiration (due to facial trauma) - presence suggest that decendent was alive shortly after landing/impact and thus likely very alive during the descent.
*+/-Haemoaspiration (due to facial trauma) - presence suggest that decendent was alive shortly after landing/impact and thus likely very alive during the descent.
**Patchy red centrilobular spots on gross examination.
**Patchy red centrilobular spots on gross examination.
==Injury patterns==
===Seromuscular tear===
* [[AKA]] ''seatbeat syndrome''.
* Intestinal injury associated with motor vehicle collisions and more specifically seatbelts.
Features:
* Def'n: separation of (inner) muscularis propria from submucosa.<ref name=pmid12198344>{{Cite journal  | last1 = Slavin | first1 = RE. | last2 = Borzotta | first2 = AP. | title = The seromuscular tear and other intestinal lesions in the seatbelt syndrome: a clinical and pathologic study of 29 cases. | journal = Am J Forensic Med Pathol | volume = 23 | issue = 3 | pages = 214-22 | month = Sep | year = 2002 | doi = 10.1097/01.PAF.0000023001.32202.2D | PMID = 12198344 }}</ref>


===Bite injury===
===Bite injury===
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*Bite marks, as evidence, have a limited value for identification purposes.
*Bite marks, as evidence, have a limited value for identification purposes.
**In the context of identifying a potential perpetrator, it is essential to swab the bite mark for saliva, which is rich in DNA.<ref>{{Cite journal  | last1 = Pretty | first1 = IA. | title = Forensic dentistry: 2. Bitemarks and bite injuries. | journal = Dent Update | volume = 35 | issue = 1 | pages = 48-50, 53-4, 57-8 passim | month =  | year =  | doi =  | PMID = 18277695 }}</ref>
**In the context of identifying a potential perpetrator, it is essential to swab the bite mark for saliva, which is rich in DNA.<ref>{{Cite journal  | last1 = Pretty | first1 = IA. | title = Forensic dentistry: 2. Bitemarks and bite injuries. | journal = Dent Update | volume = 35 | issue = 1 | pages = 48-50, 53-4, 57-8 passim | month =  | year =  | doi =  | PMID = 18277695 }}</ref>
====Images====
<gallery>
Image: Dog_bite.JPG | Bite injury. (WC)
</gallery>
===Aortic trauma===
*Classic location of transection of the aorta is distal the the left subclavian branch point near the insertion of the ligamentum arteriosum (e.g. peri-isthmus).<ref name=pmid1934437>{{cite journal |author=Kodali S, Jamieson WR, Leia-Stephens M, Miyagishima RT, Janusz MT, Tyers GF |title=Traumatic rupture of the thoracic aorta. A 20-year review: 1969-1989 |journal=Circulation |volume=84 |issue=5 Suppl |pages=III40–6 |year=1991 |month=November |pmid=1934437 |doi= |url=}}</ref>
*[[Aortic dissection]] due to trauma is often catastrophic. Several mechanisms have been proposed and there is a body of trauma biomechanics research that explores this.


==Trauma with delayed death==
==Trauma with delayed death==
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*[[Aortic dissection]] with subsequent rupture.
*[[Aortic dissection]] with subsequent rupture.


=Sharp force trauma=
=Sharp force injury=
===Characteristics<ref name=Ref_HospAuto111-2>{{Ref HospAuto|111-2}}</ref>===
*[[AKA]] ''sharp force trauma''.
*Incised wound (see: ''[[Forensic_pathology#Classification_of_wounds|Classification of wounds]]'').
===General===
**"Clean" edge (no contusion, no abrasion).
Injuries caused by:<ref name=Ref_HospAuto111-2>{{Ref HospAuto|111-2}}</ref>
**Well-demarcated edges.
 
Subclassified into ''cut/slash'' and ''stab'' (see: ''[[Forensic_pathology#Classification_of_wounds|Classification of wounds]]'').
 
===Weapons<ref name=Ref_HospAuto111-2>{{Ref HospAuto|111-2}}</ref>===
*Knife.
*Knife.
*Scissors - classic "Z" shape.
*Scissors - classic "Z" shape.
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*Glass.
*Glass.


=Blunt force trauma=
===Gross===
==Aortic trauma==
Features:<ref name=Ref_HospAuto111-2>{{Ref HospAuto|111-2}}</ref>
*Classic location of injury is subclavian branch point.<ref name=pmid1934437>{{cite journal |author=Kodali S, Jamieson WR, Leia-Stephens M, Miyagishima RT, Janusz MT, Tyers GF |title=Traumatic rupture of the thoracic aorta. A 20-year review: 1969-1989 |journal=Circulation |volume=84 |issue=5 Suppl |pages=III40–6 |year=1991 |month=November |pmid=1934437 |doi= |url=}}</ref>
*Incised wound (see: ''[[Wounds|Classification of wounds]]'').
*[[Aortic dissection]] due to trauma is often catastrophic.
**"Clean" edge (no contusion, no abrasion).
**Well-demarcated edges.
*+/-Hilt mark.
**Due to contact of hilt.
 
Subclassified into - see ''[[Wounds|classification of wounds]]'':
*''Cut/slash''.
*''Stab''.
*''Chop'' - a mixed injury, sharp force and blunt force.
 
====Images====
<gallery>
Image: Thorax-Messerstichwunden.jpg | Sharp force trauma - thorax. (WC)
</gallery>


=Head injuries=
=Head injuries=
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*Tears - corpus callosum.
*Tears - corpus callosum.
*Haemorrhage.
*Haemorrhage.
Other (chronic) changes:<ref name=Ref_AoGP639>{{Ref AoGP|639}}</ref>{{fact}}
*Thalamus - shrinkage.
*Enlargement of third ventricle.


DDx (medical imaging):<ref name=pmid22406792>{{Cite journal  | last1 = Kumar | first1 = S. | last2 = Gupta | first2 = V. | last3 = Aggarwal | first3 = S. | last4 = Singh | first4 = P. | last5 = Khandelwal | first5 = N. | title = Fat embolism syndrome mimicker of diffuse axonal injury on magnetic resonance imaging. | journal = Neurol India | volume = 60 | issue = 1 | pages = 100-2 | month =  | year =  | doi = 10.4103/0028-3886.93597 | PMID = 22406792 }}</ref>
DDx (medical imaging):<ref name=pmid22406792>{{Cite journal  | last1 = Kumar | first1 = S. | last2 = Gupta | first2 = V. | last3 = Aggarwal | first3 = S. | last4 = Singh | first4 = P. | last5 = Khandelwal | first5 = N. | title = Fat embolism syndrome mimicker of diffuse axonal injury on magnetic resonance imaging. | journal = Neurol India | volume = 60 | issue = 1 | pages = 100-2 | month =  | year =  | doi = 10.4103/0028-3886.93597 | PMID = 22406792 }}</ref>
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===Stains===
===Stains===
*[[Beilschowsky stain]] to highlight axonal swellings - appear 12-18 hours after injury.<ref name=Ref_Shkrum_562>{{Ref Shkrum|562}}</ref>
*[[Bielschowsky stain]] to highlight axonal swellings - appear 12-18 hours after injury.<ref name=Ref_Shkrum_562>{{Ref Shkrum|562}}</ref>
 
===IHC===
===IHC===
*Beta-amyloid precursor protein (beta-APP ''or'' APP).<ref name=pmid10050789>{{cite journal |author=Gleckman AM, Bell MD, Evans RJ, Smith TW |title=Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining |journal=Arch. Pathol. Lab. Med. |volume=123 |issue=2 |pages=146–51 |year=1999 |month=February |pmid=10050789 |doi= |url=}}</ref><ref name=pmid17368446>{{Cite journal  | last1 = Mac Donald | first1 = CL. | last2 = Dikranian | first2 = K. | last3 = Song | first3 = SK. | last4 = Bayly | first4 = PV. | last5 = Holtzman | first5 = DM. | last6 = Brody | first6 = DL. | title = Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. | journal = Exp Neurol | volume = 205 | issue = 1 | pages = 116-31 | month = May | year = 2007 | doi = 10.1016/j.expneurol.2007.01.035 | PMID = 17368446 | PMC = 1995439 }}</ref>
*Beta-amyloid precursor protein (beta-APP ''or'' APP).<ref name=pmid10050789>{{cite journal |author=Gleckman AM, Bell MD, Evans RJ, Smith TW |title=Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining |journal=Arch. Pathol. Lab. Med. |volume=123 |issue=2 |pages=146–51 |year=1999 |month=February |pmid=10050789 |doi= |url=}}</ref><ref name=pmid17368446>{{Cite journal  | last1 = Mac Donald | first1 = CL. | last2 = Dikranian | first2 = K. | last3 = Song | first3 = SK. | last4 = Bayly | first4 = PV. | last5 = Holtzman | first5 = DM. | last6 = Brody | first6 = DL. | title = Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. | journal = Exp Neurol | volume = 205 | issue = 1 | pages = 116-31 | month = May | year = 2007 | doi = 10.1016/j.expneurol.2007.01.035 | PMID = 17368446 | PMC = 1995439 }}</ref>
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**Deep brain structures, known as an "intermediary coup".
**Deep brain structures, known as an "intermediary coup".
**Dorsal surface of the cerebral hemispheres, known as "gliding contusions".
**Dorsal surface of the cerebral hemispheres, known as "gliding contusions".
*Resolve as a yellow lesion (like at other sites), known as a ''plaque jaune'' in the brain.
*Resolve as a yellow lesion (like at other sites), known as a ''[[plaque]] jaune'' in the brain.
**Classically, inferior aspect of the frontal lobe.
**Classically, inferior aspect of the frontal lobe.


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#Suspected toxicologic death - need details on drugs.
#Suspected toxicologic death - need details on drugs.


====Mandated by case<ref>{{Ref OPMfP|14}}</ref>====
====Mandated by case====
*Sudden death in children under five years old.
In Ontario, the following are mandated by the case:<ref>{{Ref OPMfP|14}}</ref>
*Workplace deaths.
*Sudden death of child under five years old.
*Fatal motor vehicle collision.
*Workplace death.
*Aviation deaths.
*Fatal motor vehicle collision - esp. driver.
*Fire-related deaths (carboxyhemoglobin).
*Aviation death - esp. pilot & co-pilot.
*Fire-related death (carboxyhemoglobin).


===Toxins===
===Toxins===
====Ethanol toxicity====
====Ethanol toxicity====
{{Main|Ethanol abuse}}
*Usually measured (in Canada) as: ''mass of EtOH (mg)/volume of blood (mL)''.
*Usually measured (in Canada) as: ''mass of EtOH (mg)/volume of blood (mL)''.
**Limit (Ontario): 80 milligrams of alcohol in 100 millilitres of blood (0.08 gm/100 mL).<ref>URL: [http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml]. Accessed on: 28 September 2010.</ref>
**Limit (Ontario): 80 milligrams of alcohol in 100 millilitres of blood (0.08 gm/100 mL).<ref>URL: [http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml]. Accessed on: 28 September 2010.</ref>
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====Cocaine toxicity====
====Cocaine toxicity====
*No agreed upon toxic dose<ref name=pmid15075681>{{cite journal |author=Stephens BG, Jentzen JM, Karch S, Wetli CV, Mash DC |title=National Association of Medical Examiners position paper on the certification of cocaine-related deaths |journal=Am J Forensic Med Pathol |volume=25 |issue=1 |pages=11–3 |year=2004 |month=March |pmid=15075681 |doi= |url=}}</ref> - due to tolerance.
*No agreed upon toxic dose<ref name=pmid15075681>{{cite journal |author=Stephens BG, Jentzen JM, Karch S, Wetli CV, Mash DC |title=National Association of Medical Examiners position paper on the certification of cocaine-related deaths |journal=Am J Forensic Med Pathol |volume=25 |issue=1 |pages=11–3 |year=2004 |month=March |pmid=15075681 |doi= |url=}}</ref> - due to tolerance.
*Usual mechanism ''cardiac failure''.


Features (see: ''[[cocaine toxicity]]''):
Features - heart:
*Usually anatomically normal heart.
*Usually anatomically normal heart.
*+/-Advanced atherosclerosis for age.
**+/-Advanced [[coronary artery atherosclerosis]] for age.
*+/-Infarction.
**+/-[[Myocardial infarction]].
*+/-Contraction band necrosis.
***+/-Contraction band necrosis.
*+/-Cardiac hypertrophy.
**+/-Cardiac hypertrophy.
 
Other:
*+/-Nasal septum perforation.
*+/-Track marks (other drug use).
*+/-Finger burns (during preparation of crack).
*+/-Drug paraphernalia, e.g. crack pipe.


====Ethylene glycol toxicity====
====Ethylene glycol toxicity====
:For a more general discussion see ''[[Crystals_in_body_fluids#Urine_crystals|urine crystals]]''
:For a more general discussion see ''[[Crystals_in_body_fluids#Urine_crystals|urine crystals]]''
*Not done in routine toxicology screening.
*Not done in routine toxicology screening.
*Birefringent calcium oxalate crystals found in kidney (with polarized light).<ref name=Ref_KFP589>{{Ref KFP|589}}</ref>
*Birefringent calcium oxalate crystals found in kidney (with [[polarized light]]).<ref name=Ref_KFP589>{{Ref KFP|589}}</ref>


====Anaphylaxis====
====Anaphylaxis====
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Generally, these things are:
Generally, these things are:
*Cardiovascular:
*Cardiovascular:
**Arrhythmia.
**[[Cardiac arrhythmia|Arrhythmia]].
**Myocardial infarction.
**[[Myocardial infarction]].
**Haemorrhage.
**Haemorrhage.
***Ruptured aneurysm.
***Ruptured aneurysm.
Line 805: Line 860:
*GI:
*GI:
**Haemorrhage.
**Haemorrhage.
***Esophageal varices.
***[[Esophageal varices]].
***Gastric varices.
***Gastric varices.
*Neurologic:
*Neurologic:
**Intracranial haemorrhage.
**Intracranial haemorrhage.
***Ruptured aneurysm.
***Ruptured aneurysm.
***Spontaneous subdural haemorrhage.
***Spontaneous [[subdural hemorrhage]].
**Stroke:
**[[Stroke]]:
***Haemorrhagic.
***Haemorrhagic.
***Thrombotic (more common than haemorrhagic).
***Thrombotic (more common than hemorrhagic).


=Forensic entomology=
=Forensic entomology=
Michael
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