Follicular bronchitis/bronchiolitis
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Follicular bronchitis/bronchiolitis is an uncommon type of medical lung disease.
General
- Similar to lymphocytic interstitial pneumonia (LIP).
- Overlaps with LIP.[1]
- Associated with the things seen in LIP;[2] however, associations may be less clear in children.[3]
Gross/radiology
- No distinct nodule or mass.
- Classically: increased reticular marking, i.e. interstitial pattern.
Images: Intersitial pattern - radiographs (ucsf.edu).
Microscopic
Features:[4]
- Peribronchiolar/peribronchial lymphoid nodules with:
- Reactive germinal centres.
- Lack of these should raise suspicion for lymphoma.
- Plasma cells.
- Reactive germinal centres.
- +/-Lymphoid nodules in the interlobular septa.
Notes:
- Lung parenchyma distant from nodule = normal; no lymphocytic infiltrate.
DDx:
- Lymphoma, specifically MALTomas/BALTomas.
- Lymphocytic interstitial pneumonia.
- Nodular lymphoid hyperplasia.
- This is determined in part by radiology; it has nodules radiographically.
See also
References
- ↑ Nicholson AG (August 2001). "Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung". Semin Respir Crit Care Med 22 (4): 409–22. doi:10.1055/s-2001-17384. PMID 16088689.
- ↑ Aerni MR, Vassallo R, Myers JL, Lindell RM, Ryu JH (February 2008). "Follicular bronchiolitis in surgical lung biopsies: clinical implications in 12 patients". Respir Med 102 (2): 307–12. doi:10.1016/j.rmed.2007.07.032. PMID 17997299.
- ↑ Kinane BT, Mansell AL, Zwerdling RG, Lapey A, Shannon DC (October 1993). "Follicular bronchitis in the pediatric population". Chest 104 (4): 1183–6. PMID 8404188.
- ↑ AFIP atlas of nontumour pathology. 2002. Vo. 2. P.277. ISBN 1-881041-79-4.