Difference between revisions of "Diffuse lung diseases"

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Diffuse lung diseases (view source)

Revision as of 02:57, 31 May 2014

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→‎Organizing pneumonia: split out
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==Organizing pneumonia==
==Organizing pneumonia==
===General===
{{Main|Organizing pneumonia}}
*Multiple causes, e.g. transplant rejection, infection.
 
Clinical diagnoses:<ref name=Ref_WMSP91>{{Ref WMSP|91}}</ref>
*[[Lung transplant pathology|Transplant rejection]].
*Cryptogenic organizing pneumonia (COP), [[AKA]] (idiopathic) bronchiolitis obliterans organizing pneumonia (BOOP).
**Should '''not''' be confused with ''[[constrictive bronchiolitis]]'' (AKA ''[[bronchiolitis obliterans]]'').
*[[Collagen vascular disease]].
*Toxic injury.
*Infection.
*Peri-tumor - in proximity to a space-occupying lesion (abscess, neoplasm).
 
Note:
*BOOP is used as a synonym for ''organizing pneumonia'' which has the long differential diagnosis above.<ref name=Ref_WMSP91>{{Ref WMSP|91}}</ref>
**Confusingly, it may be used to refer to the idiopathic form of organizing pneumonia, now generally known as ''cryptogenic organizing pneumonia'' (COP).
***In other words, strictly speaking, ''BOOP'' is '''not''' the same as ''COP''; idiopathic BOOP ''is'' COP.
 
===Microscopic===
Features:<ref name=Ref_Klatt110>{{Ref Klatt|110}}</ref>
*Distal airway disease -- airways plugged with organizing exudate ("[[Masson bodies]]").
**"Organized exudate" = fluffy light-staining paucicellular regions with stellate cells (fibroblasts & immature connective tissue).
*'''No''' hobnailing of pneumocytes.
**Type 2 pneumocytes hyperplasia is absent.
 
DDx:
*[[Diffuse alveolar damage]], proliferative phase - has type 2 pneumoncyte hyperplasia.
*[[Bronchiolitis obliterans]].
 
====Images====
<gallery>
Image:Masson_body_-_intermed_mag.jpg | Masson body - intermed. mag. (WC/Nephron)
Image:Masson_body_-_very_high_mag.jpg | Masson body - very high mag. (WC/Nephron)
</gallery>
www:
*[http://150.59.224.157/pathology/system/data/image_data/11338411170518.jpg Masson body (150.59.224.157)].<ref>URL: [http://150.59.224.157/pathology/index.php?first_category_id=2&second_category_id=20 http://150.59.224.157/pathology/index.php?first_category_id=2&second_category_id=20]. Accessed on: 4 August 2011.</ref>
*[http://casereports.bmj.com/content/2011/bcr.11.2010.3483.full BOOP (bmj.com)].
*[http://www.flickr.com/photos/pulmonary_pathology/4733384977/ Masson body (flickr.com)].


==Hypersensitivity pneumonitis==
==Hypersensitivity pneumonitis==
Michael
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