Difference between revisions of "Cystic nephroma, adult type"
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'''Cystic nephroma''' is a rare [[kidney tumours|kidney tumour]]. | '''Cystic nephroma''' is a rare, benign [[kidney tumours|kidney tumour]]. | ||
Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> have suggested that ''[[cystic nephroma]]'' and ''[[mixed epithelial and stromal tumour]] (MEST)'' are one tumour; the lumping term is ''renal epithelial and stromal tumour'' (abbreviated ''REST''). | Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> have suggested that ''[[cystic nephroma]]'' and ''[[mixed epithelial and stromal tumour]] (MEST)'' are one tumour; the lumping term is ''renal epithelial and stromal tumour'' (abbreviated ''REST''). | ||
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==General== | ==General== | ||
*Rare.<ref name=pmid20427881>{{Cite journal | last1 = Mohanty | first1 = D. | last2 = Jain | first2 = BK. | last3 = Agrawal | first3 = V. | last4 = Gupta | first4 = A. | title = Cystic nephroma: a diagnostic dilemma. | journal = Saudi J Kidney Dis Transpl | volume = 21 | issue = 3 | pages = 518-20 | month = May | year = 2010 | doi = | PMID = 20427881 }}</ref> | *Rare.<ref name=pmid20427881>{{Cite journal | last1 = Mohanty | first1 = D. | last2 = Jain | first2 = BK. | last3 = Agrawal | first3 = V. | last4 = Gupta | first4 = A. | title = Cystic nephroma: a diagnostic dilemma. | journal = Saudi J Kidney Dis Transpl | volume = 21 | issue = 3 | pages = 518-20 | month = May | year = 2010 | doi = | PMID = 20427881 }}</ref> | ||
*Good prognosis.<ref name=pmid20427881/> | *Good prognosis/benign.<ref name=pmid20427881/><ref name=pmid19172100/> | ||
*Considered to be on a spectrum with ''cystic partially differentiated [[nephroblastoma]]'' and ''[[Wilms tumour]].<ref name=pmid19172100>{{Cite journal | last1 = van den Hoek | first1 = J. | last2 = de Krijger | first2 = R. | last3 = van de Ven | first3 = K. | last4 = Lequin | first4 = M. | last5 = van den Heuvel-Eibrink | first5 = MM. | title = Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. | journal = Urol Int | volume = 82 | issue = 1 | pages = 65-70 | month = | year = 2009 | doi = 10.1159/000176028 | PMID = 19172100 }}</ref> | *Considered to be on a spectrum with ''cystic partially differentiated [[nephroblastoma]]'' and ''[[Wilms tumour]].<ref name=pmid19172100>{{Cite journal | last1 = van den Hoek | first1 = J. | last2 = de Krijger | first2 = R. | last3 = van de Ven | first3 = K. | last4 = Lequin | first4 = M. | last5 = van den Heuvel-Eibrink | first5 = MM. | title = Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. | journal = Urol Int | volume = 82 | issue = 1 | pages = 65-70 | month = | year = 2009 | doi = 10.1159/000176028 | PMID = 19172100 }}</ref> | ||
Revision as of 06:07, 14 November 2014
Cystic nephroma is a rare, benign kidney tumour.
Turbiner et al.[1] have suggested that cystic nephroma and mixed epithelial and stromal tumour (MEST) are one tumour; the lumping term is renal epithelial and stromal tumour (abbreviated REST).
General
- Rare.[2]
- Good prognosis/benign.[2][3]
- Considered to be on a spectrum with cystic partially differentiated nephroblastoma and Wilms tumour.[3]
Gross
- Bubble wrap-like appearance.
Image
Bubble wrap. (WC)
www:
Microscopic
Features:
- Cysts lined by simple epithelium with hobnailing - key feature.
- Stroma has an ovarian look:
- Blue (basophilic).
- Spindle cells.
Notes:
- Parenchymal elements (e.g. glomueruli, tubules) are not found in the septa between the cysts.
Images
Cystic nephroma - low mag. (WC/Nephron)
Cystic nephroma - intermed. mag. (WC/Nephron)
IHC
Features:
- ER +ve.
- PR +ve.
- CD10 +ve.
See also
References
- ↑ Turbiner, J.; Amin, MB.; Humphrey, PA.; Srigley, JR.; De Leval, L.; Radhakrishnan, A.; Oliva, E. (Apr 2007). "Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term.". Am J Surg Pathol 31 (4): 489-500. doi:10.1097/PAS.0b013e31802bdd56. PMID 17414095.
- ↑ 2.0 2.1 2.2 Mohanty, D.; Jain, BK.; Agrawal, V.; Gupta, A. (May 2010). "Cystic nephroma: a diagnostic dilemma.". Saudi J Kidney Dis Transpl 21 (3): 518-20. PMID 20427881.
- ↑ 3.0 3.1 van den Hoek, J.; de Krijger, R.; van de Ven, K.; Lequin, M.; van den Heuvel-Eibrink, MM. (2009). "Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas.". Urol Int 82 (1): 65-70. doi:10.1159/000176028. PMID 19172100.