Difference between revisions of "Brenner tumour"

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#redirect [[Ovarian tumours#Brenner tumour]]
The '''Brenner tumour''' is an [[ovarian tumour]] in the epithelial group of ovarian tumours.


==General==
*Fits into the ''transistional cell tumours'' category - in the surface epithelial group of ovarian tumours.
===Epidemiology===
*Mostly benign clinical course.
*Thought to arise from [[Walthard cell rest]].
*Frequently an incidental finding, i.e. oophorectomy was done for another reason.
*May be malignant.
==Gross==
Features:<ref name=pmid21897739>{{Cite journal  | last1 = Borah | first1 = T. | last2 = Mahanta | first2 = RK. | last3 = Bora | first3 = BD. | last4 = Saikia | first4 = S. | title = Brenner tumor of ovary: An incidental finding. | journal = J Midlife Health | volume = 2 | issue = 1 | pages = 40-1 | month = Jan | year = 2011 | doi = 10.4103/0976-7800.83273 | PMID = 21897739 |PMC = 3156501}}</ref>
*Classically solid, well-circumscribed, light yellow.
*May be cystic.
Note:
*Borderline tumours classically solid and cystic with papillary projections into the cystic component.<ref name=pmid21897739/>
==Microscopic==
Features:
*Nests of transitional epithelium with cells that have:<ref name=Ref_PBoD1098>{{Ref PBoD|1098}}</ref>
**A "[[coffee bean nucleus]]".
***Elliptical shape (nucleus).
***Nuclear grooves.<ref name=pathout_brenner>URL: [http://www.pathologyoutlines.com/ovarytumor.html#brennergen http://www.pathologyoutlines.com/ovarytumor.html#brennergen]. Accessed on: 8 February 2011.</ref>
***Distinct nucleoli.
**Moderate-to-abundant gray/pale cytoplasm.
*Dense fibrous stroma around nests.
Notes:
*Main DDx of Coffee bean nucleus = [[granulosa cell tumour]].
*Stromal component may be predominant.
DDx:
*[[Ovarian fibroma]].
*[[Thecoma]].
===Images===
<gallery>
Image:Brenner tumour high mag cropped.jpg | BT - cropped - high mag. (WC)
Image:Brenner tumour high mag.jpg | BT - high mag. (WC)
Image:Brenner tumour intermed mag.jpg | BT - intermed. mag. (WC)
</gallery>
==See also==
*[[Ovarian tumours]].
==References==
{{Reflist|2}}
[[Category:Ovarian tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 09:09, 14 February 2014

The Brenner tumour is an ovarian tumour in the epithelial group of ovarian tumours.

General

  • Fits into the transistional cell tumours category - in the surface epithelial group of ovarian tumours.

Epidemiology

  • Mostly benign clinical course.
  • Thought to arise from Walthard cell rest.
  • Frequently an incidental finding, i.e. oophorectomy was done for another reason.
  • May be malignant.

Gross

Features:[1]

  • Classically solid, well-circumscribed, light yellow.
  • May be cystic.

Note:

  • Borderline tumours classically solid and cystic with papillary projections into the cystic component.[1]

Microscopic

Features:

  • Nests of transitional epithelium with cells that have:[2]
    • A "coffee bean nucleus".
      • Elliptical shape (nucleus).
      • Nuclear grooves.[3]
      • Distinct nucleoli.
    • Moderate-to-abundant gray/pale cytoplasm.
  • Dense fibrous stroma around nests.

Notes:

DDx:

Images

  • BT - cropped - high mag. (WC)

  • BT - high mag. (WC)

  • BT - intermed. mag. (WC)

See also

References

  1. ↑ 1.0 1.1 Borah, T.; Mahanta, RK.; Bora, BD.; Saikia, S. (Jan 2011). "Brenner tumor of ovary: An incidental finding.". J Midlife Health 2 (1): 40-1. doi:10.4103/0976-7800.83273. PMC 3156501. PMID 21897739. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156501/.
  2. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1098. ISBN 0-7216-0187-1.
  3. ↑ URL: http://www.pathologyoutlines.com/ovarytumor.html#brennergen. Accessed on: 8 February 2011.
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