Difference between revisions of "Biphenotypic sinonasal sarcoma"

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'''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]].
'''Biphenotypic sinonasal sarcoma''', abbreviated '''SNS''',<ref name=pmid24859338/> is a rare bland appearing [[cancer|malignant]] tumour of the [[head and neck pathology|head and neck]].


It is also known as '''low grade sinonasla sarcoma with neural and myogenic features''', abbreviated '''LGSSNMF'''.
It is also known as '''low grade sinonasal sarcoma with neural and myogenic features''', abbreviated '''LGSSNMF'''.


==General==
==General==

Revision as of 16:09, 13 March 2016

Biphenotypic sinonasal sarcoma, abbreviated SNS,[1] is a rare bland appearing malignant tumour of the head and neck.

It is also known as low grade sinonasal sarcoma with neural and myogenic features, abbreviated LGSSNMF.

General

  • Rare.
  • Female predominant.

Microscopic

Features;

  • Bland hypercellular stroma typically without many mitoses.
  • Invaginating glandular epithelium.

DDx:

IHC

  • Actin +ve.
  • S-100 +ve (strong).

Molecular

  • PAX3-MAML3 fusion - t(2;4)(q35;q31.1).[1]

See also

References

  1. 1.0 1.1 Wang, X.; Bledsoe, KL.; Graham, RP.; Asmann, YW.; Viswanatha, DS.; Lewis, JE.; Lewis, JT.; Chou, MM. et al. (Jul 2014). "Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.". Nat Genet 46 (7): 666-8. doi:10.1038/ng.2989. PMID 24859338.