Anaplastic thyroid carcinoma
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Anaplastic thyroid carcinoma is a rare aggressive tumour of the thyroid gland.
General
Epidemiology:
- Very rare.
- Horrible prognosis - median survival of 8 months in one series.[1]
- Often presents with obstruction.
- Typically there is a history of a thyroid mass.
Microscopic
Features:
Notes:
- May have features of other thyroid carcinomas, e.g. psammoma bodies, papillae, nuclear changes of PTC.
DDx:
- Poorly differentiated thyroid carcinoma.
- Squamous cell carcinoma.
- Medullary thyroid carcinoma.
- Sarcoma.
Images
Anaplastic thyroid carcinoma with a component of PTC. (WC)
IHC
- Keratin (AE1/AE3) +ve.
- Vimentin +ve, >90%.[2]
- Thyroglobulin - rarely +ve (~15%).[2]
- CEA -ve, calcitonin -ve; to r/o medullary.
- p53 +ve.
- TTF-1 +ve.
See also
References
- ↑ Mohebati, A.; Dilorenzo, M.; Palmer, F.; Patel, SG.; Pfister, D.; Lee, N.; Tuttle, RM.; Shaha, AR. et al. (May 2014). "Anaplastic thyroid carcinoma: a 25-year single-institution experience.". Ann Surg Oncol 21 (5): 1665-70. doi:10.1245/s10434-014-3545-5. PMID 24554064.
- ↑ 2.0 2.1 Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA (July 1991). "Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases". Am. J. Clin. Pathol. 96 (1): 15–24. PMID 1712540.