Adenocarcinoma

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Adenocarcinoma is a form of cancer that arises from glandular tissue. Adenocarcinoma can arise in many sites.

Adenocarcinoma not otherwise specified, also adenocarcinoma NOS, is a non-specific malignant diagnosis that without further information is not very useful for treatment decisions.

Types of adenocarcinoma

Site specific

Gastrointestinal pathology

Esophagus

Stomach

Duodenum

Pancreas

Gallbladder

Colon and rectum

Other

Lung

Salivary gland

Gynecologic pathology

Ovary

Endometrium

Cervix

Genitourinary pathology

Prostate

Testis

General type

Microscopic (generic)

Features:

  • Gland forming - round/ovoid/tubular spaces.
  • Eccentric nucleus.
  • Moderate cytoplasm.
  • +/-Prominent nucleolus.

Grading

Adenocarcinomas are often graded by their glandular component:[1]

  • Grade 1: >95% of tumour glandular.
  • Grade 2: 50-95% of tumour glandular.
  • Grade 3: <50% of tumour glandular.

References