Acquired cystic disease-associated renal cell carcinoma
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Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.
General
- Arise in the context of long-standing end-stage renal disease (ESRD).[1]
Microscopic
Features:
- Tubular strucutres with cribriforming.
- Hobnail cells.
- Oxylate crystals - important.
- Look somewhat like cholesterol clefts.
DDx:
IHC
Features:[1]
- AMACR +ve.
- CD10 +ve.
- Pankeratin +ve.
- CK7 +ve (heterogeneous).
Others:[1]
- CD68 -ve.
- PAX2 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.