Lymph nodes with isolated tumour cells
Lymph nodes with isolated tumour cells, also isolated tumour cells (abbreviated ITCs) and isolated cancer cells, is the presence of rare cancer cells in a lymph node.
This article is focus on isolated tumour cells in breast pathology.
General
Definition
- An isolated cluster of tumour cells within a lymph node in one tissue section measuring <= 0.2 mm or <200 tumour cells.[1][2]
Significance
- Not a significant predictor of outcome in breast pathology.[3]
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Right Breast, Modified Radical Mastectomy:
- Two lymph nodes of six lymph nodes with ISOLATED TUMOR CELLS
(<100 tumour cells per lymph node).
-- All lymph nodes NEGATIVE for micrometatases and
NEGATIVE for macrometatases (0/4).
- Scar and therapy changes (hyalization, calcifications) compatible
with treated tumour.
- Florid epithelial hyperplasia of the usual type.
- Please see synoptic report.
Comment:
The isolated tumour cells were demonstrated with a CAM5.2 immunostain.
See also
References
- ↑ Reed, J.; Rosman, M.; Verbanac, KM.; Mannie, A.; Cheng, Z.; Tafra, L. (Mar 2009). "Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University/Anne Arundel Medical Center Sentinel Node Multicenter Study.". J Am Coll Surg 208 (3): 333-40. doi:10.1016/j.jamcollsurg.2008.10.036. PMID 19317993.
- ↑ Naidoo, K.; Pinder, SE. (Aug 2016). "Micro- and macro-metastasis in the axillary lymph node: A review.". Surgeon. doi:10.1016/j.surge.2016.07.002. PMID 27498412.
- ↑ Ahmed, SS.; Thike, AA.; Iqbal, J.; Yong, WS.; Tan, B.; Madhukumar, P.; Ong, KW.; Ho, GH. et al. (Mar 2014). "Sentinel lymph nodes with isolated tumour cells and micrometastases in breast cancer: clinical relevance and prognostic significance.". J Clin Pathol 67 (3): 243-50. doi:10.1136/jclinpath-2013-201771. PMID 24218025.