Acquired cystic disease-associated renal cell carcinoma

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Acquired cystic disease-associated renal cell carcinoma
Diagnosis in short

Acquired cystic disease-associated renal cell carcinoma. H&E stain.
LM sieve-like architecture (tubular structures/cribriforming), oxylate crystals - seen best in polarized light
LM DDx acquired cystic renal disease, papillary renal cell carcinoma, hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma
IHC AMACR +ve, CD10 +ve, pankeratin +ve, CK7 +ve (heterogeneous), EMA -ve
Gross kidney with cystic changes, thinned cortex
Grossing notes total nephrectomy for tumour grossing, partial nephrectomy grossing
Staging kidney cancer staging
Site kidney - see kidney tumours
Associated Dx end-stage renal disease
Prevalence rare

Acquired cystic disease-associated renal cell carcinoma, abbreviated ACD-RCC, is a rare kidney cancer that arises in the context of chronic renal failure.

General

Gross

  • Cysts.

Microscopic

Features:

  • Tubular structures with cribriforming/a sieve-like architecture.[2]
  • Oxylate crystals - important.

DDx:

Images

Case

  • ACD-RCC - very low mag.

  • ACD-RCC - low mag.

  • ACD-RCC - intermed. mag.

  • ACD-RCC - intermed. mag.

  • ACD-RCC - high mag.

  • ACD-RCC - very high mag.

  • ACD-RCC - low mag.

  • ACD-RCC - intermed. mag.

  • ACD-RCC - intermed. mag.

  • ACD-RCC - high mag.

  • ACD-RCC - high mag.

  • ACD-RCC - very high mag.

  • ACD-RCC - very high mag.

  • ACD-RCC with and without polarized light - intermed. mag.

www

IHC

Features:[1]

  • AMACR +ve.
  • CD10 +ve.
  • Pankeratin +ve.
  • CK7 +ve (heterogeneous).

Others:[1]

  • CD68 -ve.
  • PAX2 -ve.
  • EMA -ve.[4]
  • HMWCK -ve.[4]
  • Vimentin +ve/-ve.[4]
  • CAM5.2 +ve/-ve.[4]

See also

References

  1. ↑ 1.0 1.1 1.2 Ahn, S.; Kwon, GY.; Cho, YM.; Jun, SY.; Choi, C.; Kim, HJ.; Park, YW.; Park, WS. et al. (Mar 2013). "Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features.". Med Mol Morphol. doi:10.1007/s00795-013-0028-x. PMID 23471757.
  2. ↑ Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  3. ↑ 3.0 3.1 URL: https://www.auanet.org/education/modules/pathology/kidney-carcinomas/acquired-cystic.cfm. Accessed on: 13 May 2015.
  4. ↑ 4.0 4.1 4.2 4.3 Amin, Mahul B.; Eble, John; Grignon, David; Srigley, John. (2013). Urological Pathology (1st ed.). Wolters Kluwer. pp. 113. ISBN 978-0781782814.
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