Radiation esophagitis

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Radiation esophagitis is a relatively uncommon pathology of the esophagus seen in the context of radiation treatments for thoracic malignancies.

General

  • Uncommon ~1% of patients getting radiation.[1]

Gross/endoscopic

Features:

  • Erythema - nonspecific.[1]

Microscopic

Features:[1]

  • Variable inflammation.
  • Radiation-related nuclear atypia - endothelial cells and stromal cells.

DDx:

IHC

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Esophagus, 25 cm, Biopsy:
- Acute esophagitis with edema, see comment.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.

Comment:
The history of radiation is noted. 

Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.

See also

References

  1. 1.0 1.1 1.2 Murro, D.; Jakate, S. (Jun 2015). "Radiation esophagitis.". Arch Pathol Lab Med 139 (6): 827-30. doi:10.5858/arpa.2014-0111-RS. PMID 26030254.