Adenoid cystic/basal cell carcinoma of the prostate
Adenoid cystic/basal cell carcinoma of the prostate, abbreviated ACBCC, is a rare from of prostate cancer that resembles adenoid cystic carcinoma and basal cell carcinoma.
General
- Rare.
- Typically indolent - may be aggressive.[1]
Microscopic
Features:
- Adenoid cystic carcinoma-like and basal cell adenoma-like:
- Nests of cells that have round spaces filled by whispy blue mucin.
- Dense collagenous stroma.
DDx:
- Adenoid cystic-like basal cell hyperplasia.[2]
Images
ADBCC - intermed. mag.
ADBCC - intermed. mag.
ADBCC - high mag.
ADBCC - very high mag.
IHC
- HER2/neu +ve (strong).[3]
See also
References
- ↑ Iczkowski, KA.; Ferguson, KL.; Grier, DD.; Hossain, D.; Banerjee, SS.; McNeal, JE.; Bostwick, DG. (Dec 2003). "Adenoid cystic/basal cell carcinoma of the prostate: clinicopathologic findings in 19 cases.". Am J Surg Pathol 27 (12): 1523-9. PMID 14657711.
- ↑ McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.
- ↑ Iczkowski, KA.; Montironi, R. (Dec 2006). "Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu.". J Clin Pathol 59 (12): 1327-30. doi:10.1136/jcp.2005.035147. PMID 17142577.