Adenomyoepithelioma

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{{ Infobox diagnosis | Name = Adenomyoepithelioma | Image = Adenomyoepithelioma - very high mag.jpg | Width = | Caption = Adenomyoepithelioma. H&E stain. | Synonyms = | Micro = glandular architecture with: (1) identifiable myoepithelial cells with clear cytoplasm, (2) eosinophilic cuboidal epithelial cells; eosinophilic basement membrane material between glands | Subtypes = | LMDDx = invasive ductal carcinoma, mammary pleomorphic adenoma, ductal adenoma, tubular adenoma of the breast, sclerosing adenosis | Stains = | IHC = | EM = | Molecular = | IF = | Gross = | Grossing = | Site = breast | Assdx = | Syndromes = | Clinicalhx = | Signs = | Symptoms = | Prevalence = uncommon | Bloodwork = | Rads = | Endoscopy = | Prognosis = benign, occationally malignant | Other = | ClinDDx = | Tx = |} Adenomyoepithelioma is an uncommon pathology of the breast. It is usually benign.

General

  • Rare lesion consisting of epithelial and myoepithelial elements.
    • May occur in other sites, e.g. tonsil.[1]
  • May be benign or malignant.[2][3]

Note:

Microscopic

Features:[5]

  • Well-circumscribed.
  • Glandular architecture with:
    • Easily identifiable myoepithelial cells - with clear cytoplasm - key feature.
    • Eosinophilic cuboidal epithelial cells.
  • Eosinophilic basement membrane material between glands.

DDx:

Images

www:

See also

References

  1. Ren, J.; Song, L.; Dang, Q.; Zhang, X.; Jiang, SW.; Zhang, G.; Wang, N.; Liu, Z. et al. (2010). "Primary adenomyoepithelioma of tonsil.". Head Neck Oncol 2: 7. doi:10.1186/1758-3284-2-7. PMID 20356364.
  2. Howlett, DC.; Mason, CH.; Biswas, S.; Sangle, PD.; Rubin, G.; Allan, SM. (Mar 2003). "Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology.". AJR Am J Roentgenol 180 (3): 799-803. PMID 12591699. http://www.ajronline.org/content/180/3/799.full.
  3. Zizi-Sermpetzoglou, A.; Vasilakaki, T.; Grammatoglou, X.; Petrakopoulou, N.; Nikolaidou, ME.; Glava, C. (2009). "Malignant adenomyoepithelioma of the breast--case report.". Eur J Gynaecol Oncol 30 (2): 234-6. PMID 19480267.
  4. Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
  5. URL: http://www.webpathology.com/image.asp?n=1&Case=322. Accessed on: 16 August 2011.
  6. Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.