Glycogen-rich clear cell carcinoma of the breast
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| Glycogen-rich clear cell carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour, variable architecture (cords, trabeculae, clusters, cribriform), minimal nuclear pleomorphism |
| LM DDx | signet-ring cell carcinoma, lipid-rich carcinoma, apocrine carcinoma,secretory carcinoma |
| Stains | PAS +ve, PASD -ve, Oil red O -ve |
| IHC | BRST2 -ve |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | very rare |
| Prognosis | similar to NST |
Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.
It may be abbreviated GRCC.
General
- Very rare - fewer than 100 reported as cases in 2012.[1]
- Possibly a variant of apocrine carcinoma.[2]
- Prognosis similar to invasive ductal carcinoma in a smaller case-control study when match for stage.[3]
Microscopic
Features:
- Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[4]
- Various architectural arrangements: cords, trabeculae, clusters, cribriform.
- Minimal nuclear pleomorphism.
Notes:
- Histologic appearance may be similar to hyalinizing clear cell carcinoma.
DDx:
- Signet-ring cell carcinoma.
- Lipid-rich carcinoma.
- Apocrine carcinoma.
- Secretory carcinoma.
Images
www:
Stains
Features:[4]
- PAS +ve.
- PASD -ve.
Others:[4]
- Oil red O -ve.
- Lipid-rich carcinoma +ve.
IHC
Features:[3]
- BRST2 -ve.[4]
- Apocrine carcinoma +ve.
- ER +ve (~62% of cases).
- PR +ve (~62% of cases).
- HER2 -ve (~88% of cases).
See also
References
- ↑ Salemis, NS. (Aug 2012). "Intraductal glycogen-rich clear cell carcinoma of the breast: a rare presentation and review of the literature.". Breast Care (Basel) 7 (4): 319-21. doi:10.1159/000341393. PMID 23904836.
- ↑ Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
- ↑ 3.0 3.1 Ma, X.; Han, Y.; Fan, Y.; Cao, X.; Wang, X. (Jan 2014). "Clinicopathologic Characteristics and Prognosis of Glycogen-Rich Clear Cell Carcinoma of the Breast.". Breast J. doi:10.1111/tbj.12231. PMID 24400866.
- ↑ 4.0 4.1 4.2 4.3 4.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.