Glycogen-rich clear cell carcinoma of the breast
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| Glycogen-rich clear cell carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | very rare |
Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.
It may be abbreviated GRCC.
General
- Very rare.
- Possibly a variant of apocrine carcinoma.[1]
- Prognosis usually poor.
Microscopic
Features:
- Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[2]
- Various architectural arrangements: cords, trabeculae, clusters, cribriform.
- Minimal nuclear pleomorphism.
Notes:
- Histologic appearance may be similar to hyalinizing clear cell carcinoma.
DDx:
- Signet-ring cell carcinoma.
- Lipid-rich carcinoma.
- Apocrine carcinoma.
- Secretory carcinoma.
Images
www:
Stains
Features:[2]
- PAS +ve.
- PASD -ve.
Others:[2]
- Oil red O -ve.
- Lipid-rich carcinoma +ve.
IHC
Features:[2]
- BRST2 -ve.
- Apocrine carcinoma +ve.
See also
References
- ↑ Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
- ↑ 2.0 2.1 2.2 2.3 2.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.