Glycogen-rich clear cell carcinoma of the breast

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Glycogen-rich clear cell carcinoma of the breast
Diagnosis in short
Site breast - see invasive breast cancer

Prevalence very rare

Glycogen-rich clear cell carcinoma of the breast is rare type of invasive breast cancer.

It may be abbreviated GRCC.

General

Microscopic

Features:

  • Groups of cells with abundant clear cytoplasm - need to comprise 90% of the tumour.[2]
    • Various architectural arrangements: cords, trabeculae, clusters, cribriform.
    • Minimal nuclear pleomorphism.

Notes:

DDx:

Images

www:

Stains

Features:[2]

  • PAS +ve.
  • PASD -ve.

Others:[2]

  • Oil red O -ve.
    • Lipid-rich carcinoma +ve.

IHC

Features:[2]

  • BRST2 -ve.
    • Apocrine carcinoma +ve.

See also

References

  1. Hayes, MM.; Seidman, JD.; Ashton, MA. (Aug 1995). "Glycogen-rich clear cell carcinoma of the breast. A clinicopathologic study of 21 cases.". Am J Surg Pathol 19 (8): 904-11. PMID 7611537.
  2. 2.0 2.1 2.2 2.3 2.4 Thondavadi, SR.; Krishnamurthy, J.; Gubbanna, VM.. "A case report of glycogen-rich clear cell carcinoma of breast.". Indian J Pathol Microbiol 53 (2): 374-5. doi:10.4103/0377-4929.64289. PMID 20551566.