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Difference between revisions of "Pituitary gland"
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→Pituitary neuroendocrine tumor (PitNET): PIT1 lineage update
Jensflorian (talk | contribs) (→Pituitary adenoma: Starting Update on 2022 WHO classification) |
Jensflorian (talk | contribs) (→Pituitary neuroendocrine tumor (PitNET): PIT1 lineage update) |
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! Transcription factor | ! Transcription factor | ||
|- | |- | ||
| PIT1 | | PIT1 | ||
| Somatotroph tumor | |||
| Densely and sparsely granulated tumor | |||
| GH, a-subunit+/-, CK+ | |||
| PIT1 | |||
|- | |||
| PIT1 | |||
| Lactotroph tumor | |||
| Densely and sparsely granulated tumor | |||
| PRL, CK-ve or weak | |||
| PIT1, [[Estrogen receptor|ER]] | |||
|- | |- | ||
| | | PIT1 | ||
| | | Mammosomatotroph tumor | ||
| | | | ||
| PRL | | GH, PRL (usu. less), CK perinuclear +ve | ||
| PIT1, [[Estrogen receptor|ER]] | | PIT1, [[Estrogen receptor|ER]] | ||
|- | |- | ||
| PIT1 | |||
| Thyrotroph tumor | |||
| | | | ||
| | | TSH, CK-ve or weak | ||
| | | PIT1, GATA3 | ||
| TSH | |- | ||
| PIT1, [[Estrogen receptor|ER]] | | PIT1 | ||
| Mature plurihormonal PIT1 lineage tumor | |||
| | |||
| GH, PRL, TSH, a-subunit +/-ve | |||
| PIT1, [[Estrogen receptor|ER]], GATA3 | |||
|- | |- | ||
| | | | ||