Difference between revisions of "Primary mediastinal B-cell lymphoma"

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a few points
(split out)
(a few points)
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Features:<ref name=pmid19074109 >{{Cite journal  | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume =  | issue =  | pages = 349-58 | month =  | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal  | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref>  
Features:<ref name=pmid19074109 >{{Cite journal  | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume =  | issue =  | pages = 349-58 | month =  | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal  | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref>  
*Rare.
*Rare.
*Young adults.
*Young adults, more common in females (M:F = 1:2)
*[[Mediastinum]].
*[[Mediastinum]].


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DDx:
DDx:
*Other types of [[DLBCL]].
*Other types of [[DLBCL]] (radiological assessment is important - PMBCL is centred in the mediastinum)
*B-cell lymphoma with features intermediate between [[DLBCL]] and classical Hodgkins lymphoma
*Poorly differentiated carcinoma.
*Poorly differentiated carcinoma.
==IHC==
*Pan B-cell markers
*CD10 in minority (~20%)
*CD23 and CD30 expression more common (~70% and ~85% respectively)
*EBV negative


===Images===
===Images===
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Lymphoma]]
[[Category:Lymphoma]]
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