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Primary mediastinal B-cell lymphoma (view source)
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'''Primary mediastinal B-cell lymphoma''', abbreviated '''PMBL''', is an uncommon form of large B-cell lymphoma. | |||
It is also known as '''primary mediastinal large B-cell lymphoma'''. | |||
==General== | |||
Features:<ref name=pmid19074109 >{{Cite journal | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume = | issue = | pages = 349-58 | month = | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref> | |||
*Rare. | |||
*Young adults. | |||
*[[Mediastinum]]. | |||
==Microscopic== | |||
Features: | |||
*Atypical large lymphoid cells - see ''[[DLBCL]]''. | |||
*Classically associated with: | |||
**Fibrosis | |||
**Clear cells. | |||
Note: | |||
*Neither fibrosis or clear cells are required for the [[diagnosis]] nor are they pathognomonic.<ref name=pmid11251018 >{{Cite journal | last1 = van Besien | first1 = K. | last2 = Kelta | first2 = M. | last3 = Bahaguna | first3 = P. | title = Primary mediastinal B-cell lymphoma: a review of pathology and management. | journal = J Clin Oncol | volume = 19 | issue = 6 | pages = 1855-64 | month = Mar | year = 2001 | doi = | PMID = 11251018 }}</ref> | |||
DDx: | |||
*Other types of [[DLBCL]]. | |||
*Poorly differentiated carcinoma. | |||
===Images=== | |||
<gallery> | |||
Image:Primary_mediastinal_large_B-cell_lymphoma_-_very_high_mag.jpg | PMBL - very high mag. (WC) | |||
Image:Primary_mediastinal_large_B-cell_lymphoma_-_intermed_mag.jpg | PMBL - intermed. mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case371.html PMBL - several images (upmc.edu)]. | |||
==Sign out== | |||
<pre> | |||
MASS, ANTERIOR MEDIASTINAL, CORE BIOPSY: | |||
- LARGE B-CELL LYMPHOMA IN A FIBROTIC BACKGROUND WITH NECROSIS, SEE COMMENT | |||
COMMENT: | |||
Morphology: | |||
Tumour cells: size ~2x a mature lymphocyte, a moderate quantity of grey/basophilic | |||
cytoplasm, no clear cells are identified. | |||
Cells intermixed with tumour: mature lymphocytes, rare eosinophils. | |||
Architecture: no gland formation, discohesive, no follicles apparent, extensive fibrosis. | |||
Tumour cells: | |||
POSITIVE: CD45, CD20, CD10, BCL-6, BCL-2. | |||
NEGATIVE: pankeratin, PLAP, CD3, CD30. | |||
Ki-67: 50% of large (lymphoid) cells. | |||
</pre> | |||
==See also== | |||
*[[Lymphoma]]. | |||
*[[Diffuse large B-cell lymphoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymphoma]] | |||