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Difference between revisions of "Microsatellite instability in colorectal cancer"
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Microsatellite instability in colorectal cancer (view source)
Revision as of 14:02, 7 March 2016
, 14:02, 7 March 2016→IHC
(→IHC) |
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*MSH6. | *MSH6. | ||
IHC interpretation | Note: | ||
*MSI testing (in the context of suspect [[Lynch syndrome]]) can be done on adenomatous polyps;<ref name=pmid>{{Cite journal | last1 = Pino | first1 = MS. | last2 = Mino-Kenudson | first2 = M. | last3 = Wildemore | first3 = BM. | last4 = Ganguly | first4 = A. | last5 = Batten | first5 = J. | last6 = Sperduti | first6 = I. | last7 = Iafrate | first7 = AJ. | last8 = Chung | first8 = DC. | title = Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas. | journal = J Mol Diagn | volume = 11 | issue = 3 | pages = 238-47 | month = May | year = 2009 | doi = 10.2353/jmoldx.2009.080142 | PMID = 19324997 }}</ref> however, dysplasia should be present.{{fact}} | |||
===IHC interpretation=== | |||
*'''Loss of nuclear staining''' in nuclei of the tumour ''implies'' a mutation. | *'''Loss of nuclear staining''' in nuclei of the tumour ''implies'' a mutation. | ||
**Nuclear staining = normal. | **Nuclear staining = normal. | ||