Difference between revisions of "Medullary thyroid carcinoma"

Medullary thyroid carcinoma (view source)

115 bytes added , 03:36, 23 March 2015

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 *May be genetic (MEN IIa/b syndrome).
 *Arises from C cells (which produce calcitonin).
+Sporadic tumours
+*~80%
+*Slightly older age at presentation (~45)
+*Tend to be solitary
 Syndromic tumours - typically:<ref name=pmid21455198>{{Cite journal  | last1 = Nosé | first1 = V. | title = Familial thyroid cancer: a review. | journal = Mod Pathol | volume = 24 Suppl 2 | issue =  | pages = S19-33 | month = Apr | year = 2011 | doi = 10.1038/modpathol.2010.147 | PMID = 21455198 |URL = http://www.nature.com/modpathol/journal/v24/n2s/full/modpathol2010147a.html }}</ref>
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 Serology:
 *Serum calcitonin classically elevated.<ref name=pmid24470736>{{Cite journal  | last1 = Vainas | first1 = I. | last2 = Marthopoulos | first2 = A. | last3 = Chrisoulidou | first3 = A. | last4 = Raptou | first4 = K. | last5 = Tziomalos | first5 = K. | last6 = Pazaitou-Panayiotou | first6 = K. | title = Calcitonin stimulation tests for the early diagnosis and follow-up of patients with C cell disease: a descriptive analysis. | journal = Hippokratia | volume = 17 | issue = 3 | pages = 246-51 | month = Jul | year = 2013 | doi =  | PMID = 24470736 }}</ref>
+*CEA may also be elevated.
 ==Gross==