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Difference between revisions of "Chondrosarcoma"
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*This is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref> | *This is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref> | ||
==Gross== | |||
Pink and fleshy with foci of calcification. | |||
==Microscopic== | |||
*"White clouds in a blue sky". | |||
*Malignant tumor with a characteristic biphasic pattern | |||
**Cellular poorly differentiated small round blue cells | |||
**Islands of well-differentiated hyaline cartilage | |||
***Progressive maturation of cartilage towards the center | |||
***Central calcification or bone formation | |||
==IHC== | |||
*SOX9 (positive in small cells and chondrocytes) | |||
*S100 (positive in chondrocytes) | |||
*Osteocalcin (negative in small cells) | |||
==Molecular== | |||
t(8;8)(q21.1;q13.3) HEY1-NCOA2 | |||
==Photos== | |||
<gallery> | |||
*[[File:Bone Chondrosarcoma Mesenchymal MP5 PA.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal MP PA.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal LP2 PA.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal HP5 PA.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal MP2 PA.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal MP7.JPG|Islands of cartilage in a background of small blue cells.]] | |||
*[[File:Bone Chondrosarcoma Mesenchymal HP3 PA.JPG|Small blue cells predominate]] | |||
</gallery> | |||
==See also== | |||
Image: | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)]. | |||
==References== | |||
{{Reflist|1}} | |||
====Myxoid chondrosarcoma==== | ====Myxoid chondrosarcoma==== | ||