Difference between revisions of "Talk:Neuropathology"

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231 bytes added ,  14:28, 17 November 2010
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==CADASIL==
==CADASIL==
===Microscopic===
===Microscopic===
The section shows normal skin with numerous small blood vessels. The blood vessels do NOT stain with the Notch-3 immunostain. The Notch-3 control has the usual staining.  
The biopsy, containing epidermis, dermis and subcutaneous tissue, is technically satisfactory. Immunostains utilizing a monoclonal antibody 1E4 (anti-Notch-3) at dilution 1:50 shows the absence of granular deposits in the walls of small arteries and veins in the dermis and subcutaneous tissue. Immunostains are strongly positive on positive control tissue from a patient known to have CADASIL.
 
===Final diagnosis===
===Final diagnosis===
SKIN, BIOPSY:
SKIN, BIOPSY:
<br> - NO PATHOLOGIC DIAGNOSIS.
<br>- ABSENCE OF NOTCH-3 IMMUNOSTAINING.
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