Rheumatoid nodule
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Rheumatoid nodule, abbreviated RN, is a skin manifestation of rheumatoid arthritis.
| Rheumatoid nodule | |
|---|---|
| Diagnosis in short | |
 Rheumatoid nodule. H&E stain. | |
|
| |
| LM | necrotic collagen bundles with fibrin surrounded by [alisading granuloma, +/-eosinophils |
| LM DDx | granuloma annulare, necrobiosis lipoidica |
| Stains | Alcian blue (pH 2.5) -ve |
| Gross | extensor aspect of the extremities, e.g. dorsal aspect of elbow |
| Site | skin (see rheumatoid lung nodule for the lung lesion) |
|
| |
| Signs | skin nodule, close to joint - typically elbow |
| Prevalence | uncommon |
| Blood work | RF +ve |
| Prognosis | benign |
| Rheumatoid nodule | |
|---|---|
| External resources | |
| EHVSC | 10182 |
Nodules in the lung associated with rheumatoid arthritis are dealt with in rheumatoid lung nodule.
General
- Seen in rheumatoid arthritis - usually only in seropositive cases, i.e. rheumatoid factor (RF) positive.[1]
- Exceptions are reported.[2]
Gross
- Usually on the extensor aspect of the extremities, e.g. dorsal aspect of elbow.[3]
- Typically close to a joint.[citation needed]
Microscopic
- Necrotic collagen bundles with fibrin surrounded by:
- Palisading granuloma.
- +/-Eosinophils.
Notes:
- Histomorphologically very similar to Granuloma annulare.
DDx:
- Granuloma annulare - has mucin in the core of the granuloma.[4]
- Necrobiosis lipoidica.
Images
www:
- Rheumatoid nodule (granuloma.homestead.com).[5]
- Rheumatoid nodule (granuloma.homestead.com).[5]
- Rheumatoid nodule (utah.edu).[6]
Rheumatoid nodule - low mag. (WC)
Rheumatoid nodule - intermed. mag. (WC)
Rheumatoid nodule - high mag. (WC)
Stains
- Alcian blue (pH 2.5) -ve.
- Positive staining of mucin in granuloma annulare.[7]
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Submitted as "Rheumatoid Nodule Left Thumb", Excision: - Consistent with rheumatoid nodule (palisading granulomas with cores of necrobiotic collagen). - NEGATIVE for microorganisms with special stains (ZN, Grocott).
Lesion (subcutaneous), right index finger, excision: - Palisading granulomas with cores of necrobiotic collagen, consistent with rheumatoid nodule.
Micro
The sections show foci with strands of necrobiotic collagen surrounded by palisading granulomas. Rare Neutrophils are seen in the core of the granulomas. Multinucleated cells are not apparent.
Benign fibroadipose tissue and dense connective tissue are also present.
See also
References
- ↑ 1.0 1.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 299. ISBN 978-0470519035.
- ↑ Kaye, BR.; Kaye, RL.; Bobrove, A. (Feb 1984). "Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases.". Am J Med 76 (2): 279-92. PMID 6364806.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 53. ISBN 978-0443066542.
- ↑ 4.0 4.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 52. ISBN 978-0443066542.
- ↑ 5.0 5.1 URL: http://granuloma.homestead.com/palisading.html. Accessed on: 1 November 2010.
- ↑ URL: http://www.pathguy.com/lectures/joints.htm. Accessed on: 1 November 2010.
- ↑ Yun, JH.; Lee, JY.; Kim, MK.; Seo, YJ.; Kim, MH.; Cho, KH.; Kim, MB.; Lee, WS. et al. (May 2009). "Clinical and pathological features of generalized granuloma annulare with their correlation: a retrospective multicenter study in Korea.". Ann Dermatol 21 (2): 113-9. doi:10.5021/ad.2009.21.2.113. PMC 2861218. PMID 20523767. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861218/.