Medial calcific sclerosis

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Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.

Medial calcific sclerosis
Diagnosis in short
Template:Px
Medial calcific sclerosis. H&E stain.
Synonyms Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis)
LM calcifications of the tunica media
LM DDx atherosclerosis
Site blood vessels - arteries
Prognosis good
Treatment (nothing)

It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).

General

  • Usually of no clinical consequence.
  • May impact vascular assessments using ultrasound.[1]

Microscopic

Features:[2]

  • Medial calcification (purple irregular stuff on H&E -- calcium phosphate).

Note:

  • Lumen unaffected.
  • It has been suggested that it usually involves the internal elastic lamina.[3]

DDx:[4]

  • Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.

Images

  • Medial calcific sclerosis -- low mag.jpg

    MCS - low mag. (WC)

  • Medial calcific sclerosis -- intermed mag.jpg

    MCS - intermed. mag. (WC)

  • Medial calcific sclerosis -- high mag.jpg

    MCS - high mag. (WC)

  • Medial calcific sclerosis - alt -- intermed mag.jpg

    MCS - intermed. mag. (WC)

  • Medial calcific sclerosis - alt -- high mag.jpg

    MCS - high mag. (WC)

  • Calcificatio atherosclerotica.jpg

    MCS. (WC)

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RIGHT LEG, BELOW KNEE AMPUTATION:
- MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT.
- MEDIAL CALCIFIC SCLEROSIS.
- SKIN WITH DERMAL FIBROSIS.

COMMENT:
The sections may not be representative of disease in the distal vascular bed.

See also

References

  1. ↑ Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA (July 2023). "Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes". Int J Low Extrem Wounds: 15347346231191588. doi:10.1177/15347346231191588. PMID 37525549.
  2. ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 7. ISBN 978-1416002741.
  3. ↑ Micheletti RG, Fishbein GA, Currier JS, Fishbein MC (January 2008). "Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis". Arch Pathol Lab Med 132 (1): 43–7. doi:10.5858/2008-132-43-MSRACO. PMID 18181672.
  4. ↑ Dos Santos VP, Pozzan G, Castelli V, Caffaro RA (2021). "Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference?". J Vasc Bras 20: e20200211. doi:10.1590/1677-5449.200211. PMC 8276643. PMID 34290756. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276643/.
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