Laryngeal carcinoma is a subset of head and neck pathology.

Normal histology

The normal histology is dependent on the site.^[1]

Pathology

Laryngeal squamous cell carcinoma

General

95% of laryngeal carcinomas.^[2]

Risk factors:^[2]

Smoking.
Alcohol.

Note:

Asbestos exposure is also reported to be associated.^[3]

Carinoma - subclassification by site

It is generally divided the following way:^[4]

Laryngeal cancer

Supraglottis

Glottis

Subglottis

Features:^[5]^[6]

Prevalence - glottis > supraglottis > subglottis.
Glottic carcinoma tends to present earlier (as it affects phonation) and, therefore, has a better prognosis.

Microscopic

See squamous cell carcinoma.

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LEFT FALSE VOCAL CORD, BIOPSY:
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, NONKERATINIZING,
  WITH LYMPHOVASCULAR INVASION.

COMMENT:
The presence of invasive squamous cell carcinoma is confirmed by a second pathologist.

References

↑ Koren, R.; Kristt, D.; Shvero, J.; Yaniv, E.; Dekel, Y.; Gal, R. (2002). "The spectrum of laryngeal neoplasia: the pathologist's view.". Pathol Res Pract 198 (11): 709-15. PMID 12530572.
↑ ^2.0 ^2.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 396. ISBN 978-1416054542.
↑ Offermans, NS.; Vermeulen, R.; Burdorf, A.; Goldbohm, RA.; Kauppinen, T.; Kromhout, H.; van den Brandt, PA. (Jan 2014). "Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.". J Occup Environ Med 56 (1): 6-19. doi:10.1097/JOM.0000000000000060. PMID 24351898.
↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf. Accessed on: 2 May 2012.
↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 24. ISBN 978-0781765275.
↑ URL: http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/. Accessed on: 2 May 2012.

[pmid12530572-1] Koren, R.; Kristt, D.; Shvero, J.; Yaniv, E.; Dekel, Y.; Gal, R. (2002). "The spectrum of laryngeal neoplasia: the pathologist's view.". Pathol Res Pract 198 (11): 709-15. PMID 12530572.

[Ref_PCPBoD8_396-2] 2.0 ^2.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 396. ISBN 978-1416054542.

[pmid24351898-3] Offermans, NS.; Vermeulen, R.; Burdorf, A.; Goldbohm, RA.; Kauppinen, T.; Kromhout, H.; van den Brandt, PA. (Jan 2014). "Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study.". J Occup Environ Med 56 (1): 6-19. doi:10.1097/JOM.0000000000000060. PMID 24351898.

[4] URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Larynx_11protocol.pdf. Accessed on: 2 May 2012.

[Ref_WMSP24-5] Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 24. ISBN 978-0781765275.

[6] URL: http://www.health.am/cr/more/statistics-and-prognosis-for-cancer-of-the-larynx/. Accessed on: 2 May 2012.

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Laryngeal carcinoma

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