Hyaline globules
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Hyaline globules, also hyaline bodies, are a common non-specific histomorphologic feature that can be useful in formulating a differential diagnosis.
They can be seen in benign and malignant tissue.
Microscopic
Features:
- Eosinophilic (pink) round bodies ~ typically 4-10 micrometers in diameter.
Benign
- Ectopic decidua.[1]
Tumours
Gynecologic:
- Clear cell carcinoma (CCC).
- Yolk sac tumour, hepatoid pattern.[2]
Gastrointestinal:
- Solid pseudopapillary tumour.[3]
- Pancreatic endocrine tumour.[3]
- Hepatocellular carcinoma - very common.[4]
Other:
- Renal cell carcinoma.[4]
- Kaposi sarcoma (KS).
- Secretory Meningioma.[5]
- Lung adenocarcinoma.[6]
- Estimated to be present in 6% of lung adenocarcinomas (in cohort of 100 adenocarcinomas).[7]
Images
Hyaline globules in CCC - very high mag. (WC)
Hyaline globules in KS - high mag. (WC)
Hyaline globules in solid pseudopapillary tumour - very high mag. (WC)
Hyaline globules (pseudopsammoma bodies) in secretory meningioma (WC/jensflorian)
See also
References
- ↑ Dharan M (September 2009). "Hyaline globules in ectopic decidua in a pregnant woman with cervical squamous cell carcinoma". Diagn. Cytopathol. 37 (9): 696–8. doi:10.1002/dc.21113. PMID 19526574.
- ↑ URL: http://webpathology.com/image.asp?case=34&n=6. Accessed on: March 8, 2010.
- ↑ 3.0 3.1 Serra S, Chetty R (November 2008). "Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas". J. Clin. Pathol. 61 (11): 1153–9. doi:10.1136/jcp.2008.057828. PMID 18708424. http://jcp.bmj.com/content/61/11/1153.
- ↑ 4.0 4.1 Nayar, R.; Bourtsos, E.; DeFrias, DV. (Oct 2000). "Hyaline globules in renal cell carcinoma and hepatocellular carcinoma. A clue or a diagnostic pitfall on fine-needle aspiration?". Am J Clin Pathol 114 (4): 576-82. doi:10.1309/F4TU-6AFE-R7NU-39Y3. PMID 11026104.
- ↑ Budka, H. (1982). "Hyaline inclusions (Pseudopsammoma bodies) in meningiomas: immunocytochemical demonstration of epithel-like secretion of secretory component and immunoglobulins A and M.". Acta Neuropathol 56 (4): 294-8. PMID 6283779.
- ↑ Haninger DM, Kloecker GH, Bousamra Ii M, Nowacki MR, Slone SP (April 2014). "Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature". Mod Pathol 27 (4): 535–42. doi:10.1038/modpathol.2013.170. PMID 24030743.
- ↑ Scroggs MW, Roggli VL, Fraire AE, Sanfilippo F (September 1989). "Eosinophilic intracytoplasmic globules in pulmonary adenocarcinomas: a histochemical, immunohistochemical, and ultrastructural study of six cases". Hum Pathol 20 (9): 845–9. doi:10.1016/0046-8177(89)90095-6. PMID 2476374.