Basal cell hyperplasia of the prostate
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Basal cell hyperplasia of the prostate, also known as basal cell hyperplasia, is a benign change of the prostate gland that may be misdiagnosed as prostate carcinoma.
| Basal cell hyperplasia of the prostate | |
|---|---|
| Diagnosis in short | |
 Basal cell hyperplasia of prostate. H&E stain. (WC) | |
|
| |
| LM | low power gland architecture near normal, glands usually not as small as cancer, usu. lack nuclear hyperchromasia, two cell populations (as in normal prostate glands), basal cells may have nucleoli |
| LM DDx | urothelial metaplasia, prostate carcinoma |
| IHC | basal presents (p63 +ve, CK34betaE12 +ve) |
| Site | prostate gland |
|
| |
| Signs | none |
| Symptoms | none |
| Prevalence | common |
| Radiology | none |
| Prognosis | benign |
| Other | incidental microscopic finding |
| Treatment | none |
General
- Benign lesion that can be misdiagnosed as cancer.[1]
Microscopic
Features:[2]
- Low power gland architecture near normal.[3][4]
- Glands not as small as cancer.
- Folds in gland lumina.
- No nuclear hyperchromasia.
- Two cell populations (as in normal prostate glands).
- Basal cells may have nucleoli.
DDx:
- High-grade prostatic intraepithelial neoplasia - has nuclear hyperchromasia, architecture usually different (micropapillary, tufted, cribriform or flat).
- Prostatic adenocarcinoma.
- Adenoid cystic/basal cell carcinoma of the prostate - for the adenoid cystic-like pattern of BCH.[5]
- Urothelial metaplasia of the prostate - larger cells, cell borders seen.
Images
BCH - intermed. mag.
BCH - high mag.
BCH - very high mag.
BCH - very high mag.
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- Usually not reported.
See also
References
- ↑ Cleary, KR.; Choi, HY.; Ayala, AG. (Dec 1983). "Basal cell hyperplasia of the prostate.". Am J Clin Pathol 80 (6): 850-4. PMID 6195916.
- ↑ URL: http://pathologyoutlines.com/prostate.html#bch. Accessed on: 28 June 2010.
- ↑ URL: http://www.nature.com/modpathol/journal/v16/n6/fig_tab/3880810f1.html. Accessed on: 28 June 2010.
- ↑ URL: http://www.nature.com/modpathol/journal/v16/n6/fig_tab/3880810f2.html. Accessed on: 28 June 2010.
- ↑ McKenney, JK.; Amin, MB.; Srigley, JR.; Jimenez, RE.; Ro, JY.; Grignon, DJ.; Young, RH. (Oct 2004). "Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification.". Am J Surg Pathol 28 (10): 1289-98. PMID 15371944.