Adenomatoid tumour
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Adenomatoid tumour is a rare benign tumour derived from the mesothelium.
| Adenomatoid tumour | |
|---|---|
| Diagnosis in short | |
 Adenomatoid tumour. H&E stain. | |
|
| |
| LM | small tubulocystic spaces lined by unremarkable mesothelium; the pseudotubular spaces are crossed by "thread-like bridging strands, usu. well-circumscribed |
| LM DDx | lymphangioma, leiomyoma, vascular tumours |
| IHC | calretinin +ve, CK7 +ve, AE1/AE3 +ve, WT1 +ve, CD31 -ve, desmin -ve |
| Site | uterus, adnexa (fallopian tube/ovaries), others |
|
| |
| Prevalence | uncommon |
| Prognosis | benign |
| Clin. DDx | leiomyoma, other adenxal masses |
It should not be confused with the bone tumour adamantinoma.
General
- Grossly mimics leiomyoma.[1]
- Benign tumour - derived from mesothelium.
- May be seen paratesticular.[2]
Microscopic
Features:[3]
- Well-circumscribed lesion; however, not encapsulated.
- Small tubulocystic spaces lined by cytologically normal mesothelium.
DDx:
- Lymphangioma.
- Leiomyoma, esp. lipoleiomyoma.
- Vascular tumours.
Images
Adenomatoid tumour - low mag. (WC)
Adenomatoid tumour - intermed. mag. (WC)
Adenomatoid tumour - high mag. (WC)
Adenomatoid tumour - very high mag. (WC)
IHC
Features:[6]
- Calretinin +ve.
- AE1/AE3 +ve.
- CK7 +ve.[7]
Others:[7]
- CK20 -ve.
- EMA -ve.
- HMB-45 -ve.
- Vimentin -ve.
- Desmin -ve.
- CD31 -ve.
- CD34 -ve.
- WT1 +ve.[8]
See also
References
- ↑ Huang, CC.; Chang, DY.; Chen, CK.; Chou, YY.; Huang, SC. (Sep 1995). "Adenomatoid tumor of the female genital tract.". Int J Gynaecol Obstet 50 (3): 275-80. PMID 8543111.
- ↑ González Resina, R.; Carranza Carranza, A.; Congregado Córdoba, J.; Conde Sánchez, JM.; Congregado Ruiz, CB.; Medina López, R. (Jan 2010). "[Paratesticular adenomatoid tumor: a report of nine cases].". Actas Urol Esp 34 (1): 95-100. PMID 20223139.
- ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 346. ISBN 978-0443069208.
- ↑ Sangoi, AR.; McKenney, JK.; Schwartz, EJ.; Rouse, RV.; Longacre, TA. (Sep 2009). "Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.". Mod Pathol 22 (9): 1228-35. doi:10.1038/modpathol.2009.90. PMID 19543245.
- ↑ Hes, O.; Perez-Montiel, DM.; Alvarado Cabrero, I.; Zamecnik, M.; Podhola, M.; Sulc, M.; Hora, M.; Mukensnabl, P. et al. (Oct 2003). "Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors.". Ann Diagn Pathol 7 (5): 273-7. PMID 14571427.
- ↑ Canedo-Patzi, AM.; León-Bojorge, B.; de Ortíz-Hidalgo, C.. "[Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]". Gac Med Mex 142 (1): 59-66. PMID 16548294.
- ↑ 7.0 7.1 Terada, T. (Mar 2012). "An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube.". Appl Immunohistochem Mol Morphol 20 (2): 173-6. PMID 22553816.
- ↑ Schwartz, EJ.; Longacre, TA. (Apr 2004). "Adenomatoid tumors of the female and male genital tracts express WT1.". Int J Gynecol Pathol 23 (2): 123-8. PMID 15084840.