Hyperplastic polyp with perineuromatous stroma

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Hyperplastic polyp with perineuromatous stroma, also known as benign serrated colorectal fibroblastic polyps/intramucosal perineurioma and hybrid hyperplastic polyp/mucosal perineurioma, is a benign colorectal polyp.

Hyperplastic polyp with perineuromatous stroma
Diagnosis in short

Hyperplastic polyp with perineuromatous stroma. H&E stain.
Synonyms benign serrated colorectal fibroblastic polyps/intramucosal perineurioma, hybrid hyperplastic polyp/mucosal perineurioma
LM serrated epithelial cells (at the surface), perineuromatous stroma
LM DDx colonic ganglioneuroma, hyperplastic polyp
Site colon and rectum
Prevalence rare
Endoscopy polyp
Prognosis benign
Clin. DDx other types of colorectal polyps

General

  • Rare.
  • Benign.[1]

Microscopic

Features:

  • Serrated epithelial cells (at the surface of the gland) - key feature.
    • Serrated appearance = saw-tooth appearance, epithelium has jagged edge.
  • Perineuromatous stroma.

DDx:

Images

  • HP with PNS - very low mag.

  • HP with PNS - low mag.

  • HP with PNS - intermed. mag.

  • HP with PNS - intermed. mag.

  • HP with PNS - high mag.

  • HP with PNS - high mag.

  • HP with PNS - very high mag.

See also

References

  1. ↑ Agaimy, A.; Stoehr, R.; Vieth, M.; Hartmann, A. (Nov 2010). "Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutations.". Am J Surg Pathol 34 (11): 1663-71. doi:10.1097/PAS.0b013e3181f4a458. PMID 20962618.
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