Lymphocytic interstitial pneumonia

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Lymphocytic interstitial pneumonia (abbreviated LIP), also known as lymphoid interstitial pneumonia and lymphocytic interstitial pneumonitis, is an uncommon diffuse lung disease.

Lymphocytic interstitial pneumonia
Diagnosis in short

Lymphocytic interstitial pneumonia. H&E stain.

LM small mature lymphocytes in the interstitium of the lung, plasma cells, +/-lymphoid follicles
LM DDx lymphoma, follicular bronchitis/bronchiolitis, nodular lymphoid hyperplasia
Site lung - see diffuse lung diseases

Associated Dx autoimmune disorders (rheumatoid arthritis, pernicious anemia, Sjoegren syndrome), viral infections (HIV, EBV, human T-cell leukemia virus (HTLV) type 1)
Clinical history dependent on underlying cause - see associated diagnoses
Prevalence rare
Radiology basilar predominance, increased interstitial markings

General

Gross

  • Location: basilar predominance.
  • Increased interstitial markings.

Microscopic

Features:[4]

  • Small mature lymphocytes (usually B cells)[5] in the interstitium of the lung.
  • Plasma cells.
  • +/-Lymphoid follicles.

Negatives:

DDx:

Images

Case

www

Stains

To exclude infection:[6]

IHC

  • May be done to exclude lymphoma.

See also

References

  1. URL: http://emedicine.medscape.com/article/299643-overview. Accessed on: 2 June 2010.
  2. Nicholson AG (August 2001). "Lymphocytic interstitial pneumonia and other lymphoproliferative disorders in the lung". Semin Respir Crit Care Med 22 (4): 409–22. doi:10.1055/s-2001-17384. PMID 16088689.
  3. Turner, BJ.; Eppes, S.; McKee, LJ.; Cosler, L.; Markson, LE. (Jan 1995). "A population-based comparison of the clinical course of children and adults with AIDS.". AIDS 9 (1): 65-72. PMID 7893443.
  4. URL: http://emedicine.medscape.com/article/299643-diagnosis. Accessed on: 2 June 2010.
  5. AFIP atlas of nontumour pathology. 2002. Vo. 2. P.265. ISBN 1-881041-79-4.
  6. URL: http://path.upmc.edu/cases/case176/dx.html. Accessed on: 8 January 2012.