Medial calcific sclerosis

Medial calcific sclerosis is a type of arteriosclerosis that has no significant clinical impact.

Medial calcific sclerosis
Diagnosis in short
Medial calcific sclerosis. H&E stain.
Synonyms	Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis)
LM	calcifications of the tunica media
LM DDx	atherosclerosis
Site	blood vessels - arteries
Prognosis	good
Treatment	(nothing)

It is also known as Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, and Mönckeberg's arteriosclerosis (also written Monckeberg's arteriosclerosis).

General

• Usually of no clinical consequence.

Microscopic

Features:

• Medial calcification (purple irregular stuff on H&E -- calcium phosphate).

Note:

• Lumen unaffected.

DDx:

• Atherosclerosis (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.

Images

• 
  MCS - low mag. (WC)
• 
  MCS - intermed. mag. (WC)
• 
  MCS - high mag. (WC)
• 
  MCS - intermed. mag. (WC)
• 
  MCS - high mag. (WC)

• 
  MCS. (WC)

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RIGHT LEG, BELOW KNEE AMPUTATION:
- MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT.
- MEDIAL CALCIFIC SCLEROSIS.
- SKIN WITH DERMAL FIBROSIS.

COMMENT:
The sections may not be representative of disease in the distal vascular bed.

See also

• Vascular disease.