Thecoma

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Thecoma is an ovarian tumour in the sex-cord stromal group of tumours.

General

  • Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.[1]
  • Approximately 50% have symptoms related to estrogen secretion.[2]
    • May also be viralizing.

Gross

Features:

  • Solid yellow mass, usu. well-circumscribed.[3]

DDx:

Microscopic

Features:[2]

  • Nuclei with oval to spindle morphology.
  • Abundant cytoplasm that is pale, vaculolated -- key feature.

Images

  • Thecoma - low mag. (WC)

  • Thecoma - high mag. (WC)

IHC

  • Alpha-inhibin +ve (90%+).[2]

References

  1. ↑ Nocito, AL.; Sarancone, S.; Bacchi, C.; Tellez, T. (Feb 2008). "Ovarian thecoma: clinicopathological analysis of 50 cases.". Ann Diagn Pathol 12 (1): 12-6. doi:10.1016/j.anndiagpath.2007.01.011. PMID 18164409.
  2. ↑ 2.0 2.1 2.2 Cite error: Invalid <ref> tag; no text was provided for refs named pmid16810055
  3. ↑ 3.0 3.1 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.

See also

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