Post-infectious glomerulonephritis
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Post-infectious glomerulonephritis, abbreviated PIGN, is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection.
| Post-infectious glomerulonephritis | |
|---|---|
| Diagnosis in short | |
 Post-infectious glomerulonephritis. H&E stain. | |
|
| |
| LM | +/-neutrophils in glomerulus, glomerular crescents |
| EM | subepithelial deposits, hump-like |
| IF | granular immune deposits |
| Site | kidney - see medical kidney diseases |
|
| |
| Associated Dx | post-infection, e.g. pneumonia |
| Signs | nephritic syndrome (proteinuria, hypertension, azotemia, RBC casts, oliguria, hematuria) |
| Prevalence | uncommon |
| Prognosis | usually good |
General
Clinical:
Microscopic
Features:
- +/-Neutrophils - in glomerulus.
- Glomerular crescents.
Images
Post-infectious GN - high mag. (WC/Nephron)
Post-infectious GN - very high mag. (WC/Nephron)
Post-infectious GN - schematic (WC/Nephron)
www:
IF
- Granular immune deposits.
EM
- Subepithelial deposits - hump-like.[3]
- Larger when measured perpendicular to the basement membrane, if compared to membranous nephropathy.
- Typically focal.
See also
References
- ↑ Barbiano Di Belgiojoso, G.; Genderini, A.; Ferrario, F.. "[Post-infectious glomerulonephritis].". G Ital Nefrol 20 (2): 184-99. PMID 12746805.
- ↑ 2.0 2.1 Stratta, P.; Musetti, C.; Barreca, A.; Mazzucco, G. (Jun 2014). "New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.". J Nephrol 27 (3): 229-39. doi:10.1007/s40620-013-0018-z. PMID 24777751.
- ↑ Sung, HY.; Lim, CH.; Shin, MJ.; Kim, BS.; Kim, YO.; Song, HC.; Kim, SY.; Choi, EJ. et al. (Dec 2007). "A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage.". J Korean Med Sci 22 (6): 1074-8. PMID 18162726.