Lung metastasis
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Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.
| Lung metastasis | |
|---|---|
| Diagnosis in short | |
 Lung metastasis (Ewing sarcoma). H&E stain. | |
| LM DDx | primary lung cancer |
| IHC | TTF-1 (-ve useful if non-squamous), CK20 (+ve suggestive colorectal carcinoma), CK7 (-ve useful if non-squamous), GATA3 (+ve suggestive UCC) |
| Gross | lung nodules - typically multiple and peripheral |
| Site | lung |
|
| |
| Clinical history | +/-hx of cancer |
| Prevalence | relatively common |
| Radiology | peripheral lung lesions, typically multiple |
| Prognosis | usually poor |
| Clin. DDx | lung primary, abscess |
General
- Relatively common.
Gross
- Typically peripheral, multiple, well-circumscribed & white/tan masses.
- May be diffuse without obvious mass +/- septal thickening.
Prostate carcinoma. (WC/Rosen)
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Microscopic
Features:
- Variable - dependent on site of origin.
Colorectal adenocarcinoma - usually distinctive morphologically:
- Typically gland forming.
- Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
- +/-Dirty necrosis.
Others:
- Urothelial carcinoma - may mimic squamous cell carcinoma of the lung.
- Upper GI adenocarcinoma (e.g. gastric adenocarcinoma) - may mimic lung adenocarcinoma.
- Breast carcinoma - esp. ductal carcinoma of the breast - may mimic lung adenocarcinoma.
Images
Lung metastasis (ES) - intermed. mag. (WC/Nephron)
Lung metastasis (ES) - high mag. (WC/Nephron)
Lung metastasis (ES) - very high mag. (WC/Nephron)
Prostate carcinoma. (WC/Rosen)
Prostate carcinoma. (WC/Rosen)
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IHC
- TTF-1 -ve/+ve.
- Negative suggestive of metastasis... unless it is squamous carcinoma.
- CK20 +ve/-ve.
- Positive in colorectal carcinoma - very useful.
- Negative in lung primaries.
- GATA3 +ve/-ve.
- Usu. +ve in urothelial carcinoma.
- Negative in lung primaries.[1]
- CK7 -ve/+ve.
- Positive in lung adenocarcinoma and small carcinoma of the lung.
- Positive in a number of other tumours - breast, upper GI tract, thyroid, mesothelioma, salivary gland.
- Negative in poorly differentiated carcinoma of the lung and squamous carcinoma of the lung.
See also
References
- ↑ Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.