Aneurysmal bone cyst
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Aneurysmal bone cyst, abbreviated ABC, is a very common benign pathology of bone.
Giant cell reparative granuloma (also known as solid aneurysmal bone cyst) is dealth with separately.
General
Features:[1]
- Benign.
- May grow rapidly.
- Osteolysis -> cystic space -> filled with blood.
- Relatively common; in children second only to osteosarcoma.[2]
Gross/radiologic
Features:[3]
- Air-fluid levels (radiology).
- Usually metaphysis of long bones, but uncommonly the femur.
- May have an "aggressive" appearance, i.e. erode bone.
Microscopic
Features:[1]
- Bony trabeculae or osteoid tissue.
- Osteoclast giant cells.
- Multi-nucleated giant-cells with round randomly arranged nuclei.
- Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - important.
- Blood +/- surrounded by giant cells.
DDx:
- Giant cell tumour of bone - the nuclei of the cells surrounding the giant cells are similar to those in the giant cells (round nuclei).
- Telangiectatic osteosarcoma.
- Other giant cell lesions.
Images
ABC - intermed. mag. (WC/Nephron)
ABC - very high mag. (WC/Nephron)
www:
See also
- Bone.
References
- ↑ 1.0 1.1 URL: http://emedicine.medscape.com/article/1254784-overview. Accessed on: 4 February 2011.
- ↑ van den Berg H, Kroon HM, Slaar A, Hogendoorn P (2008). "Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA"". J Pediatr Orthop 28 (1): 29–35. doi:10.1097/BPO.0b013e3181558cb5. PMID 18157043.
- ↑ Parashari, UC.; Khanduri, S.; Upadhyay, D.; Bhadury, S.; Singhal, S.. "Radiologic and pathologic correlation of aneurysmal bone cysts at unusual sites.". J Cancer Res Ther 8 (1): 103-5. doi:10.4103/0973-1482.95183. PMID 22531523.