Mammary myofibroblastoma
Mammary myofibroblastoma is a rare benign pathology of the breast.
| Mammary myofibroblastoma | |
|---|---|
| Diagnosis in short | |
 Mammary myofibroblastoma. H&E stain. | |
|
| |
| LM | well-circumscribed lesion, wpindle cells without nuclear atypia arranged in fascicles, interspersed thick bundles of collagen. |
| LM DDx | metaplastic breast carcinoma, fibromatosis, leiomyoma of the breast, nodular fasciitis, phyllodes tumour |
| IHC | CD34 +ve, desmin +ve, H-caldesmon +ve, actin +ve, vimentin +ve, S100 -ve, beta-catenin -ve |
| Site | breast |
|
| |
| Clinical history | postmenopausal female or older male |
| Prevalence | rare |
| Prognosis | benign |
| Treatment | excision |
General
Note:
- In extra-mammary sites the tumour is known as a mammary-type myofibroblastoma may immunohistochemically and histomorphologically overlap with spindle cell lipoma.[3]
Microscopic
Features:[4]
- Well-circumscribed lesion.
- Spindle cells without nuclear atypia arranged in fascicles.
- Interspersed thick bundles of collagen.
Notes:
- No calcifications.
- No necrosis.
- No hemorrhage.
DDx:
- Metaplastic breast carcinoma.
- Fibromatosis.
- Leiomyoma of the breast.
- Nodular fasciitis.
- Phyllodes tumour.
- Spindle cell lipoma.
Images
Mammary myofibroblastoma - low mag. (WC/Nephron)
Mammary myofibroblastoma - intermed. mag. (WC/Nephron)
Mammary myofibroblastoma - high mag. (WC/Nephron)
www:
IHC
Features:[2]
Other
- S100 -ve.
- Beta-catenin -ve. (???)
See also
References
- ↑ Qureshi, A.; Kayani, N.. "Myofibroblastoma of breast.". Indian J Pathol Microbiol 51 (3): 395-6. PMID 18723968.
- ↑ 2.0 2.1 Mele, M.; Jensen, V.; Wronecki, A.; Lelkaitis, G. (2011). "Myofibroblastoma of the breast: Case report and literature review.". Int J Surg Case Rep 2 (6): 93-6. doi:10.1016/j.ijscr.2011.02.006. PMC 3199680. PMID 22096693. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199680/. Cite error: Invalid
<ref>tag; name "pmid22096693" defined multiple times with different content - ↑ 3.0 3.1 3.2 McMenamin, ME.; Fletcher, CD. (Aug 2001). "Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.". Am J Surg Pathol 25 (8): 1022-9. PMID 11474286.
- ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 131. ISBN 978-0443066801.