Intraductal papilloma of the breast

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Intraductal papilloma, also papilloma, is a relatively common benign pathology of the breast.

Intraductal papilloma of the breast
Diagnosis in short
Synonyms breast papilloma
LM true papillae (nipple-shaped structures with fibrovascular cores), intraductal proliferation of epithelial and myoepithelial elements, +/-hyalinization
LM DDx intraductal papilloma with florid epithelial hyperplasia, intraductal papilloma with atypical ductal hyperplasia, intraductal papilloma with ductal carcinoma in situ, invasive papillary carcinoma of the breast.
Site breast
Signs +/-nipple discharge
Prevalence common
Prognosis benign
Treatment excision

General

Microscopic

Features:

  • True papillae - nipple-shaped structures with fibrovascular cores.
  • Intraductal proliferation of epithelial and myoepithelial elements.[2]

Notes:

  • Lacks florid hyperplasia.[3]
  • May degeneration and hyalinize to form a sclerosing papilloma.

DDx:

† Size criteria are different in papillomas.

Images

  • Papillary hidradenoma - low mag. (WC/Nephron)

  • Papillary hidradenoma - very high mag. (WC/Nephron)

See also

References

  1. ↑ Zervoudis, S.; Iatrakis, G.; Economides, P.; Polyzos, D.; Navrozoglou, I. (Jan 2010). "Nipple discharge screening.". Womens Health (Lond Engl) 6 (1): 135-51. doi:10.2217/whe.09.81. PMID 20050819.
  2. ↑ "Adenoma of Nipple.". Br Med J 1 (5330): 563. Mar 1963. PMC 2123505. PMID 20789667. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2123505/?page=1.
  3. ↑ URL: http://surgpathcriteria.stanford.edu/breast/nippleadenoma/printable.html. Accessed on: 6 August 2011.
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