Embryonal carcinoma
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Embryonal carcinoma is a type of germ cell tumour. It is commonly as a component of mixed germ cell tumours.
| Embryonal carcinoma | |
|---|---|
| Diagnosis in short | |
 Embryonal carcinoma. H&E stain. | |
|
| |
| LM | vesicular nuclei, nuclear overlap, necrosis (common), mitoses, variable architecture (tubulopapillary, glandular, solid, embryoid bodies) |
| LM DDx | seminoma, mixed germ cell tumour, yolk sac tumour, other carcinomas |
| IHC | CD30 +ve, AE1/AE3 +ve |
| Site | testis, ovary, mediastinum |
|
| |
| Signs | testicular mass, pelvic mass |
General
- Affects young adults.
- May be seen in women.
Gross
- Typically a testicular mass.
- May be seen in the mediastinum.[1]
Microscopic
Features:[2]
- Nucleoli - key feature.
- Vesicular nuclei (clear, empty appearing nuclei) - key feature.
- Nuclei overlap.
- Necrosis - common.
- Not commonly present in seminoma.
- Indistinct cell borders
- Mitoses - common.
- Variable architecture:
- Tubulopapillary.
- Glandular.
- Solid.
- Embryoid bodies - ball of cells in surrounded by empty space on three sides.
Notes:
- Cytoplasmic staining variable (eosinophilic to basophilic).
DDx:
Images
Embryonal carcinoma - very high mag. - cropped (WC/Nephron)
Embryonal carcinoma - high mag. (WC/Nephron)
Embryonal carcinoma - high mag. (WC/Nephron)
Embryonal carcinoma - intermed. mag. (WC/Nephron)
Embryonal carcinoma - low mag. (WC/Nephron)
IHC
See also
References
- ↑ Yalçın, B.; Demir, HA.; Tanyel, FC.; Akçören, Z.; Varan, A.; Akyüz, C.; Kutluk, T.; Büyükpamukçu, M. (Oct 2012). "Mediastinal germ cell tumors in childhood.". Pediatr Hematol Oncol 29 (7): 633-42. doi:10.3109/08880018.2012.713084. PMID 22877235.
- ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 549. ISBN 978-0443066771.
- ↑ 3.0 3.1 Iczkowski, KA.; Butler, SL.; Shanks, JH.; Hossain, D.; Schall, A.; Meiers, I.; Zhou, M.; Torkko, KC. et al. (Feb 2008). "Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors.". Hum Pathol 39 (2): 275-81. doi:10.1016/j.humpath.2007.07.002. PMID 18045648.
- ↑ 4.0 4.1 Lau, SK.; Weiss, LM.; Chu, PG. (Mar 2007). "D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30.". Mod Pathol 20 (3): 320-5. doi:10.1038/modpathol.3800749. PMID 17277761.