Apoptosis
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Apoptosis is programmed/controlled cell death. It can be physiologic, i.e. normal, or pathologic.
Physiologic apoptosis
Examples:[1]
- Removal of self reactive lymhocytes.
- Death of cells at the end of their life:
- Neurophils.
- Enterocytes.
- Embryogenesis.
- Endometrium - during mentruation.[2]
Pathologic
- Ulcerative colitis - apoptosis increased.[3]
Microscopic
Features:[4]
- Apoptotic bodies (membrane bound cell fragments) - key feature.
- Cell shrinkage.
- Cytoplasm usu. eosinophilic (pink).
- Lack of inflammation, i.e. neutrophils.
See also
References
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 13. ISBN 978-1416054542.
- ↑ Kokawa, K.; Shikone, T.; Nakano, R. (Nov 1996). "Apoptosis in the human uterine endometrium during the menstrual cycle.". J Clin Endocrinol Metab 81 (11): 4144-7. PMID 8923873.
- ↑ Seidelin, JB.; Nielsen, OH. (2009). "Epithelial apoptosis: cause or consequence of ulcerative colitis?". Scand J Gastroenterol 44 (12): 1429-34. doi:10.3109/00365520903301212. PMID 19958058.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 4. ISBN 978-1416054542.