Anaplastic thyroid carcinoma

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Anaplastic thyroid carcinoma is a rare aggressive tumour of the thyroid gland.

General

Epidemiology:

  • Very rare.
  • Horrible prognosis.
  • Often presents with obstruction.
  • Typically there is a history of a thyroid mass.

Microscopic

Features:

Notes:

  • May have features of other thyroid carcinomas, e.g. psammoma bodies, papillae, nuclear changes of PTC.

DDx:

Images

  • Anaplastic thyroid carcinoma with a component of PTC. (WC)

IHC

  • Keratin (AE1/AE3) +ve.
  • Vimentin +ve, >90%.[1]
  • Thyroglobulin - rarely +ve (~15%).[1]
  • CEA -ve, calcitonin -ve; to r/o medullary.
  • p53 +ve.
  • TTF-1 +ve.

See also

References

  1. ↑ 1.0 1.1 Ordóñez NG, El-Naggar AK, Hickey RC, Samaan NA (July 1991). "Anaplastic thyroid carcinoma. Immunocytochemical study of 32 cases". Am. J. Clin. Pathol. 96 (1): 15–24. PMID 1712540.
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